A novel KRAS exon 2 drop-off digital PCR assay for mutation detection in cell-free DNA of cancer patients

A novel KRAS exon 2 drop-off digital PCR assay for mutation detection in cell-free DNA of cancer patients

Abstract Background KRAS exon 2 mutations are highly prevalent in human malignancies, making them attractive targets for detection and monitoring in cell-free DNA (cfDNA) of cancer patients. Drop-off assays designed for digital polymerase chain reaction (ddPCR drop-off) span entire mutational hotspo...

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Bibliographic Details
Main Authors: Bianca Addamo-De Nard, Meret Geissmann, Dilara Akhoundova, Clelia Pistoni, Tomas Brezina, Martin Zoche, Achim Weber, Saskia Hussung, Ralph Fritsch
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Diagnostic Pathology
Subjects:
Liquid biopsy
Droplet digital polymerase chain reaction (ddPCR)
KRAS
Drop-off assay
Cell-free DNA (cfDNA)
Circulating-tumor DNA (ctDNA)
Online Access:https://doi.org/10.1186/s13000-025-01637-y
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