CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects

This review provides a comprehensive overview of point-of-care (PoC) devices across several key diagnostic applications, including blood analysis, infectious disease detection, neural interfaces, and commercialized integrated circuits (ICs). In the blood analysis section, the focus is on biomarkers...

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Main Authors: Tania Moeinfard, Ebrahim Ghafar-Zadeh, Sebastian Magierowski
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Micromachines
Subjects:
Online Access:https://www.mdpi.com/2072-666X/15/11/1320
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author Tania Moeinfard
Ebrahim Ghafar-Zadeh
Sebastian Magierowski
author_facet Tania Moeinfard
Ebrahim Ghafar-Zadeh
Sebastian Magierowski
author_sort Tania Moeinfard
collection DOAJ
description This review provides a comprehensive overview of point-of-care (PoC) devices across several key diagnostic applications, including blood analysis, infectious disease detection, neural interfaces, and commercialized integrated circuits (ICs). In the blood analysis section, the focus is on biomarkers such as glucose, dopamine, and aptamers, and their respective detection techniques. The infectious disease section explores PoC technologies for detecting pathogens, RNA, and DNA, highlighting innovations in molecular diagnostics. The neural interface section reviews advancements in neural recording and stimulation for therapeutic applications. Finally, a survey of commercialized ICs from companies such as Abbott and Medtronic is presented, showcasing existing PoC devices already in widespread clinical use. This review emphasizes the role of complementary metal-oxide-semiconductor (CMOS) technology in enabling compact, efficient diagnostic systems and offers insights into the current and future landscape of PoC devices.
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spelling doaj-art-8ea4b208a73d4258b76260fe49e3a8ac2025-08-20T02:48:01ZengMDPI AGMicromachines2072-666X2024-10-011511132010.3390/mi15111320CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future ProspectsTania Moeinfard0Ebrahim Ghafar-Zadeh1Sebastian Magierowski2Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON M3J 1P3, CanadaDepartment of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON M3J 1P3, CanadaDepartment of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON M3J 1P3, CanadaThis review provides a comprehensive overview of point-of-care (PoC) devices across several key diagnostic applications, including blood analysis, infectious disease detection, neural interfaces, and commercialized integrated circuits (ICs). In the blood analysis section, the focus is on biomarkers such as glucose, dopamine, and aptamers, and their respective detection techniques. The infectious disease section explores PoC technologies for detecting pathogens, RNA, and DNA, highlighting innovations in molecular diagnostics. The neural interface section reviews advancements in neural recording and stimulation for therapeutic applications. Finally, a survey of commercialized ICs from companies such as Abbott and Medtronic is presented, showcasing existing PoC devices already in widespread clinical use. This review emphasizes the role of complementary metal-oxide-semiconductor (CMOS) technology in enabling compact, efficient diagnostic systems and offers insights into the current and future landscape of PoC devices.https://www.mdpi.com/2072-666X/15/11/1320point-of-care (PoC)CMOS technologybiomedical integrated circuits (ICs)bioimpedance spectroscopySARS-CoV-2 diagnosticsglucose monitoring
spellingShingle Tania Moeinfard
Ebrahim Ghafar-Zadeh
Sebastian Magierowski
CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects
Micromachines
point-of-care (PoC)
CMOS technology
biomedical integrated circuits (ICs)
bioimpedance spectroscopy
SARS-CoV-2 diagnostics
glucose monitoring
title CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects
title_full CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects
title_fullStr CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects
title_full_unstemmed CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects
title_short CMOS Point-of-Care Diagnostics Technologies: Recent Advances and Future Prospects
title_sort cmos point of care diagnostics technologies recent advances and future prospects
topic point-of-care (PoC)
CMOS technology
biomedical integrated circuits (ICs)
bioimpedance spectroscopy
SARS-CoV-2 diagnostics
glucose monitoring
url https://www.mdpi.com/2072-666X/15/11/1320
work_keys_str_mv AT taniamoeinfard cmospointofcarediagnosticstechnologiesrecentadvancesandfutureprospects
AT ebrahimghafarzadeh cmospointofcarediagnosticstechnologiesrecentadvancesandfutureprospects
AT sebastianmagierowski cmospointofcarediagnosticstechnologiesrecentadvancesandfutureprospects