Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants?
This study was aimed to verify the efficacy and safety of ibuprofen prophylaxis of patent ductus arteriosus in very preterm infants, in order to select infants receiving higher benefits from this intervention. Two hundred neonates with gestational age (GA) < or = 28 weeks receiving ibuprof...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2011-04-01
|
| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1749 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850025211084144640 |
|---|---|
| author | Iliana Bersani Maria Pia De Carolis Serafina Lacerenza Gabriella De Rosa Francesca Paola Fusco Francesco Cota Costantino Romagnoli |
| author_facet | Iliana Bersani Maria Pia De Carolis Serafina Lacerenza Gabriella De Rosa Francesca Paola Fusco Francesco Cota Costantino Romagnoli |
| author_sort | Iliana Bersani |
| collection | DOAJ |
| description |
This study was aimed to verify the efficacy and safety of ibuprofen prophylaxis of patent ductus arteriosus in very preterm infants, in order to select infants receiving higher benefits from this intervention. Two hundred neonates with gestational age (GA) < or = 28 weeks receiving ibuprofen within the first two hours of life were included. Ductus closure rate was 68%, and results were significantly dependent on GA (48.8% among neonates with GA < 26 weeks vs 73.2% among those with GA > or = 26 weeks, p < 0.01). Neonates with GA < 26 weeks showed a lower ductus closure after the primary course of therapy (20% vs 57.5%, p < 0.01), as well as higher reopening rate (16.2% vs 3.8%, p < 0.05) and need for surgical ligation (38.8% vs 5.8%, p < 0.01). During the prophylaxis period, 11 neonates (5.5%) showed pulmonary hypertension. Considering risks/benefits, we recommend prophylaxis only in infants with GA < 26 weeks.
|
| format | Article |
| id | doaj-art-8e9d0d020d4b48d48c4e5de162d6114f |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2011-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-8e9d0d020d4b48d48c4e5de162d6114f2025-08-20T03:00:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212011-04-01532Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants?Iliana Bersani0Maria Pia De CarolisSerafina LacerenzaGabriella De RosaFrancesca Paola FuscoFrancesco CotaCostantino RomagnoliDivision of Neonatology, Catholic University of Sacred Heart, Rome, Italy. This study was aimed to verify the efficacy and safety of ibuprofen prophylaxis of patent ductus arteriosus in very preterm infants, in order to select infants receiving higher benefits from this intervention. Two hundred neonates with gestational age (GA) < or = 28 weeks receiving ibuprofen within the first two hours of life were included. Ductus closure rate was 68%, and results were significantly dependent on GA (48.8% among neonates with GA < 26 weeks vs 73.2% among those with GA > or = 26 weeks, p < 0.01). Neonates with GA < 26 weeks showed a lower ductus closure after the primary course of therapy (20% vs 57.5%, p < 0.01), as well as higher reopening rate (16.2% vs 3.8%, p < 0.05) and need for surgical ligation (38.8% vs 5.8%, p < 0.01). During the prophylaxis period, 11 neonates (5.5%) showed pulmonary hypertension. Considering risks/benefits, we recommend prophylaxis only in infants with GA < 26 weeks. https://turkjpediatr.org/article/view/1749 |
| spellingShingle | Iliana Bersani Maria Pia De Carolis Serafina Lacerenza Gabriella De Rosa Francesca Paola Fusco Francesco Cota Costantino Romagnoli Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants? The Turkish Journal of Pediatrics |
| title | Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants? |
| title_full | Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants? |
| title_fullStr | Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants? |
| title_full_unstemmed | Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants? |
| title_short | Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants? |
| title_sort | is the prophylaxis of patent ductus arteriosus useful in extremely premature infants |
| url | https://turkjpediatr.org/article/view/1749 |
| work_keys_str_mv | AT ilianabersani istheprophylaxisofpatentductusarteriosususefulinextremelyprematureinfants AT mariapiadecarolis istheprophylaxisofpatentductusarteriosususefulinextremelyprematureinfants AT serafinalacerenza istheprophylaxisofpatentductusarteriosususefulinextremelyprematureinfants AT gabrielladerosa istheprophylaxisofpatentductusarteriosususefulinextremelyprematureinfants AT francescapaolafusco istheprophylaxisofpatentductusarteriosususefulinextremelyprematureinfants AT francescocota istheprophylaxisofpatentductusarteriosususefulinextremelyprematureinfants AT costantinoromagnoli istheprophylaxisofpatentductusarteriosususefulinextremelyprematureinfants |