Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study
Introduction Air pollution is linked with poor neurodevelopment in high-income countries. Comparable data are scant for low-income countries, where exposures are higher. Longitudinal pregnancy cohort studies are optimal for individual exposure assessment during critical windows of brain development...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-02-01
|
| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/9/1/e002758.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864888511954944 |
|---|---|
| author | John Kinuthia R Scott McClelland Barbra A Richardson Elizabeth Maleche-Obimbo Brent R Collett Sarah Benki-Nugent Faridah H Were Anne M Riederer Michael Gatari CJ Karr Edmund YW Seto Beatrice C Mutai Susan Wamithi Priscilla Wanini Edemba Timothy V Larson Julian D Marshall |
| author_facet | John Kinuthia R Scott McClelland Barbra A Richardson Elizabeth Maleche-Obimbo Brent R Collett Sarah Benki-Nugent Faridah H Were Anne M Riederer Michael Gatari CJ Karr Edmund YW Seto Beatrice C Mutai Susan Wamithi Priscilla Wanini Edemba Timothy V Larson Julian D Marshall |
| author_sort | John Kinuthia |
| collection | DOAJ |
| description | Introduction Air pollution is linked with poor neurodevelopment in high-income countries. Comparable data are scant for low-income countries, where exposures are higher. Longitudinal pregnancy cohort studies are optimal for individual exposure assessment during critical windows of brain development and examination of neurodevelopment. This study aims to determine the association between prenatal ambient air pollutant exposure and neurodevelopment in children aged 12, 24 and 36 months through a collaborative, capacity-enriching research partnership.Methods and analysis This observational cohort study is based in Nairobi, Kenya. Eligibility criteria are singleton pregnancy, no severe pregnancy complications and maternal age 18 to 40 years. At entry, mothers (n=400) are administered surveys to characterise air pollution exposures reflecting household features and occupational activities and provide blood (for lead analysis) and urine specimens (for polycyclic aromatic hydrocarbon (PAH) metabolites). Mothers attend up to two additional antenatal study visits, with urine collection, and infants are followed through age 36 months for annual neurodevelopment and caregiving behaviour assessment, and child urine and blood collection. Primary outcomes are child motor skills, language and cognition at 12, 24 and 36 months, and executive function at 36 months. The primary exposure is urinary PAH metabolite concentrations. Additional exposure assessment in a subset of the cohort includes residential indoor and outdoor air monitoring for fine particulate matter (PM2.5), carbon monoxide (CO), ultrafine particles (UFP) and black carbon (BC).Ethics and dissemination This study was approved by the Kenyatta National Hospital - University of Nairobi Ethics and Research Committee, and the University of Washington Human Subjects Division. Results are shared at annual workshops. |
| format | Article |
| id | doaj-art-8e95c056d40c4ebfac5cda4ffa099e17 |
| institution | Kabale University |
| issn | 2399-9772 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj-art-8e95c056d40c4ebfac5cda4ffa099e172025-02-08T17:00:10ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722025-02-019110.1136/bmjpo-2024-002758Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort studyJohn Kinuthia0R Scott McClelland1Barbra A Richardson2Elizabeth Maleche-Obimbo3Brent R Collett4Sarah Benki-Nugent5Faridah H Were6Anne M Riederer7Michael Gatari8CJ Karr9Edmund YW Seto10Beatrice C Mutai11Susan Wamithi12Priscilla Wanini Edemba13Timothy V Larson14Julian D Marshall15Global Health, University of Washington, Seattle, Washington, USADepartment of Global Health, University of Washington, Seattle, Washington, USAGlobal Health, University of Washington, Seattle, Washington, USADepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya3University of Washington and Seattle Children`s Hospital, Seattle, Washington, USADepartment of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USADepartment of Chemistry, University of Nairobi, Nairobi, KenyaDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USAInstitute of Nuclear Sciences, University of Nairobi, Nairobi, KenyaDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USADepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USADepartment of Paediatrics and Child Health, University of Nairobi, Nairobi, KenyaAga Khan University Medical College, Nairobi, KenyaKenyatta National Hospital, Nairobi, KenyaDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USADepartment of Civil & Environmental Engineering, University of Washington, Seattle, Washington, USAIntroduction Air pollution is linked with poor neurodevelopment in high-income countries. Comparable data are scant for low-income countries, where exposures are higher. Longitudinal pregnancy cohort studies are optimal for individual exposure assessment during critical windows of brain development and examination of neurodevelopment. This study aims to determine the association between prenatal ambient air pollutant exposure and neurodevelopment in children aged 12, 24 and 36 months through a collaborative, capacity-enriching research partnership.Methods and analysis This observational cohort study is based in Nairobi, Kenya. Eligibility criteria are singleton pregnancy, no severe pregnancy complications and maternal age 18 to 40 years. At entry, mothers (n=400) are administered surveys to characterise air pollution exposures reflecting household features and occupational activities and provide blood (for lead analysis) and urine specimens (for polycyclic aromatic hydrocarbon (PAH) metabolites). Mothers attend up to two additional antenatal study visits, with urine collection, and infants are followed through age 36 months for annual neurodevelopment and caregiving behaviour assessment, and child urine and blood collection. Primary outcomes are child motor skills, language and cognition at 12, 24 and 36 months, and executive function at 36 months. The primary exposure is urinary PAH metabolite concentrations. Additional exposure assessment in a subset of the cohort includes residential indoor and outdoor air monitoring for fine particulate matter (PM2.5), carbon monoxide (CO), ultrafine particles (UFP) and black carbon (BC).Ethics and dissemination This study was approved by the Kenyatta National Hospital - University of Nairobi Ethics and Research Committee, and the University of Washington Human Subjects Division. Results are shared at annual workshops.https://bmjpaedsopen.bmj.com/content/9/1/e002758.full |
| spellingShingle | John Kinuthia R Scott McClelland Barbra A Richardson Elizabeth Maleche-Obimbo Brent R Collett Sarah Benki-Nugent Faridah H Were Anne M Riederer Michael Gatari CJ Karr Edmund YW Seto Beatrice C Mutai Susan Wamithi Priscilla Wanini Edemba Timothy V Larson Julian D Marshall Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study BMJ Paediatrics Open |
| title | Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study |
| title_full | Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study |
| title_fullStr | Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study |
| title_full_unstemmed | Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study |
| title_short | Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study |
| title_sort | air pollution exposures in early life and brain development in children abc protocol for a pregnancy cohort study |
| url | https://bmjpaedsopen.bmj.com/content/9/1/e002758.full |
| work_keys_str_mv | AT johnkinuthia airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT rscottmcclelland airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT barbraarichardson airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT elizabethmalecheobimbo airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT brentrcollett airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT sarahbenkinugent airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT faridahhwere airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT annemriederer airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT michaelgatari airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT cjkarr airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT edmundywseto airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT beatricecmutai airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT susanwamithi airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT priscillawaniniedemba airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT timothyvlarson airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy AT juliandmarshall airpollutionexposuresinearlylifeandbraindevelopmentinchildrenabcprotocolforapregnancycohortstudy |