A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut health
Exposure to environmental pollutants increases the risk for metabolic dysfunction. Dietary and lifestyle interventions may reduce the risks associated with this toxicity. We conducted this 4-week, observational, clinical study to explore the safety and efficacy of a proprietary dietary program formu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464624006194 |
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| author | Wei Gao Joseph J. Lamb David Graham Bhargavi Manda Clinton J. Dahlberg E. Wesley Huff Michael Saunders Matthew L. Tripp |
| author_facet | Wei Gao Joseph J. Lamb David Graham Bhargavi Manda Clinton J. Dahlberg E. Wesley Huff Michael Saunders Matthew L. Tripp |
| author_sort | Wei Gao |
| collection | DOAJ |
| description | Exposure to environmental pollutants increases the risk for metabolic dysfunction. Dietary and lifestyle interventions may reduce the risks associated with this toxicity. We conducted this 4-week, observational, clinical study to explore the safety and efficacy of a proprietary dietary program formulated to enhance cardiometabolic functioning, metabolic transformation, and gut health. Thirty-eight generally healthy overweight subjects were assigned a low-glycemic load, Mediterranean-style food plan with targeted nutraceutical supplementation and a physical activity regimen. Subjects expressed positive subjective health and symptom changes coincident with improvements in anthropomorphic variables, lipid profiles, glycemic measures, vascular biomarkers, cardiovascular risk, systemic inflammation, hepatic function, urinary heavy metal excretion, and gut health. Thus combining targeted nutraceutical supplementation with a low-glycemic load food plan and exercise may represent a novel nutritional approach to improving the body's ability to modulate the toxicity of pollutants and reducing cardiometabolic risk factors in generally healthy overweight persons. |
| format | Article |
| id | doaj-art-8e8ec42082ff4b2b86dc93fb86828749 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-8e8ec42082ff4b2b86dc93fb868287492025-01-12T05:24:42ZengElsevierJournal of Functional Foods1756-46462025-01-01124106616A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut healthWei Gao0Joseph J. Lamb1David Graham2Bhargavi Manda3Clinton J. Dahlberg4E. Wesley Huff5Michael Saunders6Matthew L. Tripp7Hughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USACorresponding author.; Hughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USAHughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USAHughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USAHughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USAHughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USAHughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USAHughes Center for Research and Innovation, Nature's Sunshine Products, Inc, 2901 West Blue Grass Blvd, Lehi, UT 84043, USAExposure to environmental pollutants increases the risk for metabolic dysfunction. Dietary and lifestyle interventions may reduce the risks associated with this toxicity. We conducted this 4-week, observational, clinical study to explore the safety and efficacy of a proprietary dietary program formulated to enhance cardiometabolic functioning, metabolic transformation, and gut health. Thirty-eight generally healthy overweight subjects were assigned a low-glycemic load, Mediterranean-style food plan with targeted nutraceutical supplementation and a physical activity regimen. Subjects expressed positive subjective health and symptom changes coincident with improvements in anthropomorphic variables, lipid profiles, glycemic measures, vascular biomarkers, cardiovascular risk, systemic inflammation, hepatic function, urinary heavy metal excretion, and gut health. Thus combining targeted nutraceutical supplementation with a low-glycemic load food plan and exercise may represent a novel nutritional approach to improving the body's ability to modulate the toxicity of pollutants and reducing cardiometabolic risk factors in generally healthy overweight persons.http://www.sciencedirect.com/science/article/pii/S1756464624006194DetoxificationCardiometabolic functionMetabolic dysfunctionMediterranean dietToxic elementsGut inflammation |
| spellingShingle | Wei Gao Joseph J. Lamb David Graham Bhargavi Manda Clinton J. Dahlberg E. Wesley Huff Michael Saunders Matthew L. Tripp A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut health Journal of Functional Foods Detoxification Cardiometabolic function Metabolic dysfunction Mediterranean diet Toxic elements Gut inflammation |
| title | A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut health |
| title_full | A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut health |
| title_fullStr | A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut health |
| title_full_unstemmed | A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut health |
| title_short | A pilot, four-week, dietary program with targeted nutraceuticals improves cardiometabolic functioning, metabolic transformation, and gut health |
| title_sort | pilot four week dietary program with targeted nutraceuticals improves cardiometabolic functioning metabolic transformation and gut health |
| topic | Detoxification Cardiometabolic function Metabolic dysfunction Mediterranean diet Toxic elements Gut inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624006194 |
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