The potential effects of cranberry extract on indomethacin-induced gastric ulcer in rats [version 1; peer review: 1 approved, 2 approved with reservations]
Background Indomethacin (IND) belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for treatment of rheumatoid diseases and linked to the development of gastric ulcers in many people. Cranberry is a rich source of polyphenols and flavonoids, which have powerful antioxidant and anti-in...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2025-03-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/14-257/v1 |
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| Summary: | Background Indomethacin (IND) belongs to nonsteroidal anti-inflammatory drugs (NSAIDs) prescribed for treatment of rheumatoid diseases and linked to the development of gastric ulcers in many people. Cranberry is a rich source of polyphenols and flavonoids, which have powerful antioxidant and anti-inflammatory properties. Methods This study aimed to evaluate the activity of cranberry aqueous extract on IND-induced gastric ulcers in albino rats. Twenty-four adult male rats were sequentially assigned to four groups of six each. The control group consumes distilled water (DW) orally for 15 days. The IND (induction) group received a single oral dosage (60 mg/kg) of IND. The omeprazole (OMP) group got 60 mg/kg of IND as a single oral dose and then 20 mg/kg/day of OMP for 15 days. The cranberry group was given a single dose of IND 60 mg/kg orally and subsequently 200 mg/kg/day of cranberry aqueous extract for 15 days. Rats were euthanized on day 16, and gastric tissues were removed for biochemical and histopathological evaluations. Results Cranberry extract considerably ameliorated the severity of IND-induced gastric ulcerations and fixed histological deteriorations. Furthermore, IND-exposed rats treated with cranberry extract exhibited dramatically lower serum levels of inflammatory biomarkers like TNF-α and IL-6, but higher levels of anti-oxidative biomarkers like SOD and GPx. The bioactive flavonoids and polyphenols content of cranberry extract could possibly account for its profound gastroprotective effects. The anti-oxidative and anti-inflammatory properties of cranberry extract could be a promising strategy for ameliorating the IND-aggravated gastrotoxicity. |
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| ISSN: | 2046-1402 |