Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity

Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity

Abstract Significant data suggest that cerebral accumulation of the amyloid β-protein (Aβ) plays an initiating role in Alzheimer’s disease (AD), however, Aβ can exist in multiple different forms and it is not clear which of these contribute to the propagation of amyloid or toxicity. When injected in...

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Main Authors: Simin Song, Qianmin Liu, Ruixiang Chen, Ping Chen, Min Tao, Siyao Li, Liping Guo, Xixi Zhu, Yan Liu, Lu Liu, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Dominic M. Walsh, Zhangjin Zhang, Wei Hong
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Amyloid β-protein
Cognitive impairment
Gliosis
Neuronal loss
Neurotoxicity
Prion-like spreading
Online Access:https://doi.org/10.1186/s40478-025-02032-w
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