4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling

4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling

Abstract Aim Sepsis-induced vascular injury is a major contributor to the high mortality rate of sepsis. However, effective treatments remain elusive due to limited knowledge regarding the underlying molecular mechanisms. Itaconic acid, an endogenous metabolite, involved in multiple inflammatory dis...

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Main Authors: Rong Li, Yu Ma, Haoran Wu, Xiao Zhang, Nianhui Ding, Zhichao Li, Xin Hu, Jiajia Rao, Yiting Zhou, Liqun Wang, Ying Wan, Yan Yang, Jianbo Wu, Xiaoqin Zhang, Chunxiang Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
Sepsis
Acute lung injury
Endothelial cell
4-Octyl Itaconate
Vascular injury
Online Access:https://doi.org/10.1186/s10020-025-01160-2
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