How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5T
Background: Cardiovascular magnetic resonance (CMR) is the gold standard for assessing cardiac volumes and function using two-dimensional (2D) breath-held cine imaging. This technique, however, requires a reliable electrocardiogram (ECG) signal, repetitive breath-holds, and the time-consuming and pr...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664725000250 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849725938050269184 |
|---|---|
| author | Robert J. Holtackers Augustin C. Ogier Ludovica Romanin Estelle Tenisch Isabel Montón Quesada Ruud B. van Heeswijk Christopher W. Roy Jérôme Yerly Milan Prsa Matthias Stuber |
| author_facet | Robert J. Holtackers Augustin C. Ogier Ludovica Romanin Estelle Tenisch Isabel Montón Quesada Ruud B. van Heeswijk Christopher W. Roy Jérôme Yerly Milan Prsa Matthias Stuber |
| author_sort | Robert J. Holtackers |
| collection | DOAJ |
| description | Background: Cardiovascular magnetic resonance (CMR) is the gold standard for assessing cardiac volumes and function using two-dimensional (2D) breath-held cine imaging. This technique, however, requires a reliable electrocardiogram (ECG) signal, repetitive breath-holds, and the time-consuming and proficiency-demanding planning of cardiac views. Recently, a free-running framework has been developed for cardiac and respiratory motion-resolved five-dimensional (5D) whole-heart imaging without the need for an ECG signal, repetitive breath-holds, and meticulous plan scanning. In this study, we investigate the impact of acquisition time on cardiac volumetric and functional measurements, when using free-running imaging, compared to reference standard 2D cine imaging. Methods: Sixteen healthy adult volunteers underwent CMR at 1.5T, including standard 2D breath-held cine imaging and free-running imaging using acquisition durations ranging from 1 to 6 min in randomized order. All datasets were anonymized and analyzed for left-ventricular end-systolic volume (ESV) and end-diastolic volume (EDV), as well as ejection fraction (EF). In a subset of data, intra- and inter-observer agreement was assessed. In addition, image quality and observer confidence were scored using a 4-point Likert scale. Finally, acquisition efficiency was reported for both imaging techniques, which was defined as the time required for data sampling divided by the total scan time. Results: No significant differences in left-ventricular EDV and ESV were found between free-running imaging for 1, 2, 3, 5, and 6 min and standard 2D breath-held cine imaging. Biases in EDV ranged from −2.4 to −7.4 mL, while biases in ESV ranged from −3.8 to 2.1 mL. No significant differences in EF were found between free-running imaging of any acquisition duration and standard 2D breath-held cine imaging. Biases in EF ranged from −2.8% to 0.94%. Both image quality and observer confidence in free-running imaging improved when the acquisition duration increased. However, they were always lower than standard 2D breath-held cine imaging. Acquisition efficiency improved from 13% for standard 2D cine imaging to 50% or higher for free-running imaging. Conclusion: Free-running CMR with an acquisition duration as short as 1min can provide left-ventricular cardiac volumes and EF comparable to standard 2D breath-held cine imaging, albeit at the expense of both image quality and observer confidence. |
| format | Article |
| id | doaj-art-8e830f2e0c1649fb9753ce964dd84c3d |
| institution | DOAJ |
| issn | 1097-6647 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-8e830f2e0c1649fb9753ce964dd84c3d2025-08-20T03:10:21ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472025-01-0127110186310.1016/j.jocmr.2025.101863How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5TRobert J. Holtackers0Augustin C. Ogier1Ludovica Romanin2Estelle Tenisch3Isabel Montón Quesada4Ruud B. van Heeswijk5Christopher W. Roy6Jérôme Yerly7Milan Prsa8Matthias Stuber9Department of Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands; Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Corresponding author.Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, SwitzerlandDivision of Pediatric Cardiology, Woman-Mother-Child Department, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, SwitzerlandBackground: Cardiovascular magnetic resonance (CMR) is the gold standard for assessing cardiac volumes and function using two-dimensional (2D) breath-held cine imaging. This technique, however, requires a reliable electrocardiogram (ECG) signal, repetitive breath-holds, and the time-consuming and proficiency-demanding planning of cardiac views. Recently, a free-running framework has been developed for cardiac and respiratory motion-resolved five-dimensional (5D) whole-heart imaging without the need for an ECG signal, repetitive breath-holds, and meticulous plan scanning. In this study, we investigate the impact of acquisition time on cardiac volumetric and functional measurements, when using free-running imaging, compared to reference standard 2D cine imaging. Methods: Sixteen healthy adult volunteers underwent CMR at 1.5T, including standard 2D breath-held cine imaging and free-running imaging using acquisition durations ranging from 1 to 6 min in randomized order. All datasets were anonymized and analyzed for left-ventricular end-systolic volume (ESV) and end-diastolic volume (EDV), as well as ejection fraction (EF). In a subset of data, intra- and inter-observer agreement was assessed. In addition, image quality and observer confidence were scored using a 4-point Likert scale. Finally, acquisition efficiency was reported for both imaging techniques, which was defined as the time required for data sampling divided by the total scan time. Results: No significant differences in left-ventricular EDV and ESV were found between free-running imaging for 1, 2, 3, 5, and 6 min and standard 2D breath-held cine imaging. Biases in EDV ranged from −2.4 to −7.4 mL, while biases in ESV ranged from −3.8 to 2.1 mL. No significant differences in EF were found between free-running imaging of any acquisition duration and standard 2D breath-held cine imaging. Biases in EF ranged from −2.8% to 0.94%. Both image quality and observer confidence in free-running imaging improved when the acquisition duration increased. However, they were always lower than standard 2D breath-held cine imaging. Acquisition efficiency improved from 13% for standard 2D cine imaging to 50% or higher for free-running imaging. Conclusion: Free-running CMR with an acquisition duration as short as 1min can provide left-ventricular cardiac volumes and EF comparable to standard 2D breath-held cine imaging, albeit at the expense of both image quality and observer confidence.http://www.sciencedirect.com/science/article/pii/S1097664725000250CMRCardiac MRI5DFree-runningSelf-gatingFree-breathing |
| spellingShingle | Robert J. Holtackers Augustin C. Ogier Ludovica Romanin Estelle Tenisch Isabel Montón Quesada Ruud B. van Heeswijk Christopher W. Roy Jérôme Yerly Milan Prsa Matthias Stuber How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5T Journal of Cardiovascular Magnetic Resonance CMR Cardiac MRI 5D Free-running Self-gating Free-breathing |
| title | How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5T |
| title_full | How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5T |
| title_fullStr | How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5T |
| title_full_unstemmed | How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5T |
| title_short | How low can we go? The effect of acquisition duration on cardiac volume and function measurements in free-running cardiac and respiratory motion-resolved five-dimensional whole-heart cine magnetic resonance imaging at 1.5T |
| title_sort | how low can we go the effect of acquisition duration on cardiac volume and function measurements in free running cardiac and respiratory motion resolved five dimensional whole heart cine magnetic resonance imaging at 1 5t |
| topic | CMR Cardiac MRI 5D Free-running Self-gating Free-breathing |
| url | http://www.sciencedirect.com/science/article/pii/S1097664725000250 |
| work_keys_str_mv | AT robertjholtackers howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT augustincogier howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT ludovicaromanin howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT estelletenisch howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT isabelmontonquesada howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT ruudbvanheeswijk howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT christopherwroy howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT jeromeyerly howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT milanprsa howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t AT matthiasstuber howlowcanwegotheeffectofacquisitiondurationoncardiacvolumeandfunctionmeasurementsinfreerunningcardiacandrespiratorymotionresolvedfivedimensionalwholeheartcinemagneticresonanceimagingat15t |