Colonic perforation as an unusual manifestation of Behcet's disease
Introduction. Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as litle as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnose...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2011-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501111992T.pdf |
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| author | Tomić-Lučić Aleksandra Jovanović Snežana Petronijević Milan Veselinović Mirjana |
| author_facet | Tomić-Lučić Aleksandra Jovanović Snežana Petronijević Milan Veselinović Mirjana |
| author_sort | Tomić-Lučić Aleksandra |
| collection | DOAJ |
| description | Introduction. Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as litle as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnosed with Behcet's disease who underwent both surgical and conversative treatment due to perforation of the colon. Case report. A 34-year-old patient was admitted to the hospital with fever, aphthous ulcerations on oral mucosa and genitals and bilateral uveitis. On the basis of clinical symptoms and the International Criteria developed in 1990 Behcet's disease was diagnosed. During the next few days the patient developed erythema nodosum, diarrheic syndrome and acute abdominal symptoms due to perforation of the transverse colon. An emergent laparotomy was undertaken involving resection of a perforated segment of the colon, and bipolar colostomy on the left side of abdomen. Following the surgery the patient was treated except for antibiotics with three successive pulse doses of methylprednisolone (500 mg/daily) and cyclophosphamide (15 mg/kg). The treatment was continued by gradual decrease in the close of the corticosteroid (perorally) and by cyclophosphamide first with monthly doses (5 monthly pulse doses of 15 mg/kg cyclophosphoamide), and then with 3-month doses (totally 6 doses) up to totally 12 g. Conclusion. The therapy with pulse doses of methylprednisolone combined with pulse doses of cyclophosphamide was very effective in the reported case with the complex clinical manifestations leading to resolution of gastrointenstinal, ocular and orogenital lesions. |
| format | Article |
| id | doaj-art-8e802c343e5846c7b077fce99ba5877a |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-8e802c343e5846c7b077fce99ba5877a2025-08-20T03:07:17ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502011-01-01681199299510.2298/VSP1111992TColonic perforation as an unusual manifestation of Behcet's diseaseTomić-Lučić AleksandraJovanović SnežanaPetronijević MilanVeselinović MirjanaIntroduction. Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as litle as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnosed with Behcet's disease who underwent both surgical and conversative treatment due to perforation of the colon. Case report. A 34-year-old patient was admitted to the hospital with fever, aphthous ulcerations on oral mucosa and genitals and bilateral uveitis. On the basis of clinical symptoms and the International Criteria developed in 1990 Behcet's disease was diagnosed. During the next few days the patient developed erythema nodosum, diarrheic syndrome and acute abdominal symptoms due to perforation of the transverse colon. An emergent laparotomy was undertaken involving resection of a perforated segment of the colon, and bipolar colostomy on the left side of abdomen. Following the surgery the patient was treated except for antibiotics with three successive pulse doses of methylprednisolone (500 mg/daily) and cyclophosphamide (15 mg/kg). The treatment was continued by gradual decrease in the close of the corticosteroid (perorally) and by cyclophosphamide first with monthly doses (5 monthly pulse doses of 15 mg/kg cyclophosphoamide), and then with 3-month doses (totally 6 doses) up to totally 12 g. Conclusion. The therapy with pulse doses of methylprednisolone combined with pulse doses of cyclophosphamide was very effective in the reported case with the complex clinical manifestations leading to resolution of gastrointenstinal, ocular and orogenital lesions.http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501111992T.pdfBehctet syndromeintestinal perforationcolontherapeuticssurgical procedures, operativecyclophosphamidemethylprednisolone |
| spellingShingle | Tomić-Lučić Aleksandra Jovanović Snežana Petronijević Milan Veselinović Mirjana Colonic perforation as an unusual manifestation of Behcet's disease Vojnosanitetski Pregled Behctet syndrome intestinal perforation colon therapeutics surgical procedures, operative cyclophosphamide methylprednisolone |
| title | Colonic perforation as an unusual manifestation of Behcet's disease |
| title_full | Colonic perforation as an unusual manifestation of Behcet's disease |
| title_fullStr | Colonic perforation as an unusual manifestation of Behcet's disease |
| title_full_unstemmed | Colonic perforation as an unusual manifestation of Behcet's disease |
| title_short | Colonic perforation as an unusual manifestation of Behcet's disease |
| title_sort | colonic perforation as an unusual manifestation of behcet s disease |
| topic | Behctet syndrome intestinal perforation colon therapeutics surgical procedures, operative cyclophosphamide methylprednisolone |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2011/0042-84501111992T.pdf |
| work_keys_str_mv | AT tomiclucicaleksandra colonicperforationasanunusualmanifestationofbehcetsdisease AT jovanovicsnezana colonicperforationasanunusualmanifestationofbehcetsdisease AT petronijevicmilan colonicperforationasanunusualmanifestationofbehcetsdisease AT veselinovicmirjana colonicperforationasanunusualmanifestationofbehcetsdisease |