Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse

Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse

Abstract Cingulin (CGN) is a cytoskeleton‐associated protein localized at the apical junctions of epithelial cells. CGN interacts with major cytoskeletal filaments and regulates RhoA activity. However, physiological roles of CGN in development and human diseases are currently unknown. Here, we repor...

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Bibliographic Details
Main Authors: Guang‐Jie Zhu, Yuhang Huang, Linqing Zhang, Keji Yan, Cui Qiu, Yihan He, Qing Liu, Chengwen Zhu, Matías Morín, Miguel Ángel Moreno‐Pelayo, Min‐Sheng Zhu, Xin Cao, Han Zhou, Xiaoyun Qian, Zhigang Xu, Jie Chen, Xia Gao, Guoqiang Wan
Format: Article
Language:English
Published: Springer Nature 2023-09-01
Series:EMBO Molecular Medicine
Subjects:
ADNSHL
cingulin
cuticular plate
hair cells
hearing loss
Online Access:https://doi.org/10.15252/emmm.202317611
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