Lipid infiltration promotes trans-differentiation of vascular smooth muscle cells into macrophage-like cells in early lesions of human coronary atherosclerosis

Lipid infiltration promotes trans-differentiation of vascular smooth muscle cells into macrophage-like cells in early lesions of human coronary atherosclerosis

Abstract Background The trans-differentiation of vascular smooth muscle cells (VSMCs) into macrophage-like phenotypes contributes substantially to the advancement of atherosclerotic lesions. However, it remains uncertain whether this trans-differentiation is involved in the early pathogenesis of hum...

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Bibliographic Details
Main Authors: Junhai Hao, Jiang Liu, Jiahui Zhou, Yuanfeng Liang, Wanwen Chen, Yueheng Wu, Zhanyi Lin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Lipids in Health and Disease
Subjects:
Lipid metabolism
Muscle, smooth, vascular
Fatty acid-binding proteins
Atherosclerosis
Online Access:https://doi.org/10.1186/s12944-025-02662-y
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