Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase Model
This study investigates the atomization process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers (SMIs) using a validated Volume of Fluid (VOF)-to-Discrete Phase Model (DPM) to simulate the transition from colliding liquid jets to aerosolized droplets. Key parameters,...
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2025-03-01
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| author | Ted Sperry Yu Feng |
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| description | This study investigates the atomization process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers (SMIs) using a validated Volume of Fluid (VOF)-to-Discrete Phase Model (DPM) to simulate the transition from colliding liquid jets to aerosolized droplets. Key parameters, including colliding jet inlet velocity, surface tension, and liquid viscosity, were systematically varied to analyze their impact on the atomization, i.e., aerosolized droplet size distributions. The VOF-to-DPM simulation results indicate that higher jet inlet velocities enhance ligament fragmentation, producing finer and more uniform droplets while reducing total atomized droplet mass. The relationship between surface tension and atomization performance in colliding jet atomization is not monotonic. Reducing surface tension plays a complex dual role in the atomization process. On the one hand, lower surface tension enhances the likelihood of liquid jet breakup into a liquid sheet, leading to the formation of smaller ligaments under the same airflow conditions and shear forces. This increases the probability of generating more secondary droplets. On the other hand, reduced surface tension also destabilizes the liquid surface shape, decreasing the formation of fine, high-sphericity droplets in regimes where surface tension is a dominant force. Viscosity also influences atomization through complex mechanisms, i.e., lower viscosity reduces resistance to ligament breakup but promotes droplet interactions and coalescence, while higher viscosity suppresses ligament fragmentation, generating larger droplets and reducing atomization efficiency. The validated VOF-to-DPM framework provides critical insights for enhancing the performance and efficiency of inhalation therapies. Future work will incorporate nozzle geometry, jet impingement angles, and surfactant effects to better understand and optimize the atomization process in SMIs, focusing on achieving preferred droplet size distributions and emitted doses for enhanced drug delivery efficiency in human respiratory systems. |
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| institution | OA Journals |
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| language | English |
| publishDate | 2025-03-01 |
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| series | Bioengineering |
| spelling | doaj-art-8e7538fae2b848ea8451043c09f494302025-08-20T02:11:00ZengMDPI AGBioengineering2306-53542025-03-0112326410.3390/bioengineering12030264Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase ModelTed Sperry0Yu Feng1School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USASchool of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USAThis study investigates the atomization process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers (SMIs) using a validated Volume of Fluid (VOF)-to-Discrete Phase Model (DPM) to simulate the transition from colliding liquid jets to aerosolized droplets. Key parameters, including colliding jet inlet velocity, surface tension, and liquid viscosity, were systematically varied to analyze their impact on the atomization, i.e., aerosolized droplet size distributions. The VOF-to-DPM simulation results indicate that higher jet inlet velocities enhance ligament fragmentation, producing finer and more uniform droplets while reducing total atomized droplet mass. The relationship between surface tension and atomization performance in colliding jet atomization is not monotonic. Reducing surface tension plays a complex dual role in the atomization process. On the one hand, lower surface tension enhances the likelihood of liquid jet breakup into a liquid sheet, leading to the formation of smaller ligaments under the same airflow conditions and shear forces. This increases the probability of generating more secondary droplets. On the other hand, reduced surface tension also destabilizes the liquid surface shape, decreasing the formation of fine, high-sphericity droplets in regimes where surface tension is a dominant force. Viscosity also influences atomization through complex mechanisms, i.e., lower viscosity reduces resistance to ligament breakup but promotes droplet interactions and coalescence, while higher viscosity suppresses ligament fragmentation, generating larger droplets and reducing atomization efficiency. The validated VOF-to-DPM framework provides critical insights for enhancing the performance and efficiency of inhalation therapies. Future work will incorporate nozzle geometry, jet impingement angles, and surfactant effects to better understand and optimize the atomization process in SMIs, focusing on achieving preferred droplet size distributions and emitted doses for enhanced drug delivery efficiency in human respiratory systems.https://www.mdpi.com/2306-5354/12/3/264Soft Mist inhaler (SMI)volume of fluid-to-discrete phase model (VOF-to-DPM)atomizationemitted droplet size distribution |
| spellingShingle | Ted Sperry Yu Feng Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase Model Bioengineering Soft Mist inhaler (SMI) volume of fluid-to-discrete phase model (VOF-to-DPM) atomization emitted droplet size distribution |
| title | Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase Model |
| title_full | Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase Model |
| title_fullStr | Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase Model |
| title_full_unstemmed | Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase Model |
| title_short | Prediction of the Atomization Process in Respimat<sup>®</sup> Soft Mist<sup>TM</sup> Inhalers Using a Volume of Fluid-to-Discrete Phase Model |
| title_sort | prediction of the atomization process in respimat sup r sup soft mist sup tm sup inhalers using a volume of fluid to discrete phase model |
| topic | Soft Mist inhaler (SMI) volume of fluid-to-discrete phase model (VOF-to-DPM) atomization emitted droplet size distribution |
| url | https://www.mdpi.com/2306-5354/12/3/264 |
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