Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee Osteoarthritis
Osteoarthritis (OA) is an age-related disorder that causes painful and disabling joint pathologies and cartilage deterioration. Therapies based on mesenchymal stromal cells (MSCs) offer a novel regenerative treatment option for patients with knee OA. Joint-resident MSCs reside in joint and bone cavi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Formosan Journal of Musculoskeletal Disorders |
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| Online Access: | https://journals.lww.com/10.4103/fjmd.FJMD-D-23-00004 |
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| author | Hsiu-Jung Liao Chih-Hung Chang |
| author_facet | Hsiu-Jung Liao Chih-Hung Chang |
| author_sort | Hsiu-Jung Liao |
| collection | DOAJ |
| description | Osteoarthritis (OA) is an age-related disorder that causes painful and disabling joint pathologies and cartilage deterioration. Therapies based on mesenchymal stromal cells (MSCs) offer a novel regenerative treatment option for patients with knee OA. Joint-resident MSCs reside in joint and bone cavity niches, including the bone marrow, synovium, synovial fluid, and adipose tissue; these are primary MSC sources that are abundant in vivo and occupy multiple niches, making them ideal channels for therapeutic interventions against OA. MSCs migrate adjacent to the joint cavity during embryogenesis and provide crucial support for chondrogenesis. In adulthood, joint-resident MSCs serve as primary drivers of cartilage repair, and MSC reservoirs can be utilized for treating human articular cartilage injury because of their high cartilaginous production. This review summarizes the features of joint-resident MSCs and focuses on their application in therapies for knee OA. |
| format | Article |
| id | doaj-art-8e748a9c296747d8a2de6963404d7d69 |
| institution | OA Journals |
| issn | 2210-7940 2210-7959 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Formosan Journal of Musculoskeletal Disorders |
| spelling | doaj-art-8e748a9c296747d8a2de6963404d7d692025-08-20T02:08:46ZengWolters Kluwer Medknow PublicationsFormosan Journal of Musculoskeletal Disorders2210-79402210-79592024-04-01152434810.4103/fjmd.FJMD-D-23-00004Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee OsteoarthritisHsiu-Jung LiaoChih-Hung ChangOsteoarthritis (OA) is an age-related disorder that causes painful and disabling joint pathologies and cartilage deterioration. Therapies based on mesenchymal stromal cells (MSCs) offer a novel regenerative treatment option for patients with knee OA. Joint-resident MSCs reside in joint and bone cavity niches, including the bone marrow, synovium, synovial fluid, and adipose tissue; these are primary MSC sources that are abundant in vivo and occupy multiple niches, making them ideal channels for therapeutic interventions against OA. MSCs migrate adjacent to the joint cavity during embryogenesis and provide crucial support for chondrogenesis. In adulthood, joint-resident MSCs serve as primary drivers of cartilage repair, and MSC reservoirs can be utilized for treating human articular cartilage injury because of their high cartilaginous production. This review summarizes the features of joint-resident MSCs and focuses on their application in therapies for knee OA.https://journals.lww.com/10.4103/fjmd.FJMD-D-23-00004cartilage repairjoint-resident mesenchymal stromal cellsosteoarthritis |
| spellingShingle | Hsiu-Jung Liao Chih-Hung Chang Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee Osteoarthritis Formosan Journal of Musculoskeletal Disorders cartilage repair joint-resident mesenchymal stromal cells osteoarthritis |
| title | Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee Osteoarthritis |
| title_full | Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee Osteoarthritis |
| title_fullStr | Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee Osteoarthritis |
| title_full_unstemmed | Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee Osteoarthritis |
| title_short | Use of Joint-resident Mesenchymal Stromal Cells for Articular Cartilage Repair in Degenerative Knee Osteoarthritis |
| title_sort | use of joint resident mesenchymal stromal cells for articular cartilage repair in degenerative knee osteoarthritis |
| topic | cartilage repair joint-resident mesenchymal stromal cells osteoarthritis |
| url | https://journals.lww.com/10.4103/fjmd.FJMD-D-23-00004 |
| work_keys_str_mv | AT hsiujungliao useofjointresidentmesenchymalstromalcellsforarticularcartilagerepairindegenerativekneeosteoarthritis AT chihhungchang useofjointresidentmesenchymalstromalcellsforarticularcartilagerepairindegenerativekneeosteoarthritis |