Identification of essential proteins based on ranking edge-weights in protein-protein interaction networks.

Identification of essential proteins based on ranking edge-weights in protein-protein interaction networks.

Essential proteins are those that are indispensable to cellular survival and development. Existing methods for essential protein identification generally rely on knock-out experiments and/or the relative density of their interactions (edges) with other proteins in a Protein-Protein Interaction (PPI)...

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Bibliographic Details
Main Authors: Yan Wang, Huiyan Sun, Wei Du, Enrico Blanzieri, Gabriella Viero, Ying Xu, Yanchun Liang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0108716&type=printable
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