Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy

Saved in:

Bibliographic Details
Main Authors:	Changyoun Kim, Edward Rockenstein, Brian Spencer, Hyung-Koo Kim, Anthony Adame, Margarita Trejo, Klodjan Stafa, He-Jin Lee, Seung-Jae Lee, Eliezer Masliah
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124725006588
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Nicotine-mediated effects in neuronal and mouse models of synucleinopathy
by: Mohamed Bilal Fares, et al.
Published: (2023-08-01)

Correction: Nicotine-mediated effects in neuronal and mouse models of synucleinopathy
by: Mohamed Bilal Fares, et al.
Published: (2025-08-01)

Retraction Notice to “Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy” [Neurobiology of Disease 104 (2017) 85–96]
by: Omar El-Agnaf, et al.
Published: (2025-03-01)

Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.
by: Valeriy Duka, et al.
Published: (2013-01-01)

A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.
by: Edward Rockenstein, et al.
Published: (2015-01-01)

Microglia-driven inflammation induces progressive tauopathies and synucleinopathies
by: Sang Hwan Lee, et al.
Published: (2025-05-01)

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies
by: Marc Emmenegger, et al.
Published: (2021-07-01)

Correction: Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease.
by: Brian Spencer, et al.
Published: (2025-01-01)

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.
by: Brian Spencer, et al.
Published: (2011-01-01)

Lipid metabolites affected by deficient autophagy antagonize the occurrence of autophagy through AMPK signaling in insects
by: Ling Tian, et al.
Published: (2025-07-01)

RETRACTED ARTICLE: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 – implications for dementia with Lewy bodies
by: Cassia R Overk, et al.
Published: (2014-05-01)

Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5– implications for dementia with lewy bodies
by: Cassia R Overk, et al.
Published: (2025-08-01)

Templating of monomeric alpha-synuclein results in inflammation and SNpc dopamine neuron death in a genetic mouse model of induced synucleinopathy
by: Matthew D. Byrne, et al.
Published: (2025-07-01)

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies
by: Sungwon An, et al.
Published: (2025-08-01)

Astrocyte alterations in α-synucleinopathies
by: Manuela Rodríguez-Castañeda, et al.
Published: (2025-08-01)

Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model
by: Jiqing Xu, et al.
Published: (2016-08-01)

Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in Caenorhabditis elegans
by: Hyemin Kim, et al.
Published: (2025-12-01)

Positron emission tomography tracers for synucleinopathies
by: Jie Xiang, et al.
Published: (2025-01-01)

Alpha-Synuclein Dysregulation in Systemic Pathophysiology of Synucleinopathies
by: Hallie H. Dolin, et al.
Published: (2025-07-01)

The Potential of iPS Cells in Synucleinopathy Research
by: Leonhard Linta, et al.
Published: (2012-01-01)

Lactoferrin as a Candidate Multifunctional Therapeutic in Synucleinopathies
by: Caroline A. Barros, et al.
Published: (2025-04-01)

Retraction Note: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies
by: Changyoun Kim, et al.
Published: (2025-03-01)

Author Correction: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies
by: Changyoun Kim, et al.
Published: (2023-07-01)

RETRACTED ARTICLE: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies
by: Changyoun Kim, et al.
Published: (2022-01-01)

Effects of tianeptine on mTORC1-mediated neuronal autophagy in primary rat hippocampal neurons under nutrient deprivation
by: Mi Kyoung Seo, et al.
Published: (2025-04-01)

Peripheral cutaneous synucleinopathy characteristics in genetic Parkinson’s disease
by: Yanpeng Yuan, et al.
Published: (2024-05-01)

Enhancing sleep quality in synucleinopathies through physical exercise
by: Jacopo Canonichesi, et al.
Published: (2025-01-01)

Editorial: The contribution of autophagy to neuronal metabolism
by: Francois Singh, et al.
Published: (2025-04-01)

Rice stripe mosaic virus M protein antagonizes G-protein-induced antiviral autophagy in insect vectors
by: Ruonan Zhang, et al.
Published: (2025-04-01)

Toxoplasma GRA16 attenuates Tau hyperphosphorylation and enhances autophagy in thrombin-treated HT-22 hippocampal neuronal cells
by: Seung-Hwan Seo, et al.
Published: (2025-05-01)

Phosphorylated α-synuclein in CSF and plasma does not reflect synucleinopathy
by: Giovanni Bellomo, et al.
Published: (2025-08-01)

Correction: Peripheral cutaneous synucleinopathy characteristics in genetic Parkinson's disease
by: Yanpeng Yuan, et al.
Published: (2025-08-01)

Clinical utility of synuclein skin biopsy in the diagnosis and evaluation of synucleinopathies
by: Jonathan R. Isaacson, et al.
Published: (2024-12-01)

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy
by: Virginia Gao, et al.
Published: (2025-05-01)

Neuronal fatty acid-binding protein enhances autophagy and suppresses amyloid-β pathology in a Drosophila model of Alzheimer's disease.
by: Seokhui Jang, et al.
Published: (2024-11-01)

A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies
by: Jamir Pitton Rissardo, et al.
Published: (2025-03-01)

The prodromal individuals’ perspective on active recruitment for early detection of α-synucleinopathies
by: Sinah Röttgen, et al.
Published: (2025-05-01)

Glycoprotein 130 Antagonism Counteracts Autophagy-Mediated Metabolic Derangements and Improves Right Ventricle Function in Pulmonary Artery Banded Pigs
by: Jenna Mendelson, et al.
Published: (2025-06-01)

Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons
by: Zhenyuan Zhang, et al.
Published: (2025-10-01)

Neuronal autosis: the self-destructive side of autophagy involved in hypoxic-ischemic neuronal death
by: Vanessa Ginet, et al.
Published: (2025-12-01)