Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic Syndrome
Metabolic disorders, including obesity and type 2 diabetes, have reached epidemic proportions globally, necessitating novel therapeutic approaches. The gut-brain axis, particularly gut hormones, plays a crucial role in metabolic regulation, offering promising targets for intervention. This review ai...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2025-05-01
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| Series: | Iranian Journal of Diabetes and Obesity |
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| Online Access: | http://ijdo.ssu.ac.ir/article-1-955-en.pdf |
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| author | Tamer A. Addissouky |
| author_facet | Tamer A. Addissouky |
| author_sort | Tamer A. Addissouky |
| collection | DOAJ |
| description | Metabolic disorders, including obesity and type 2 diabetes, have reached epidemic proportions globally, necessitating novel therapeutic approaches. The gut-brain axis, particularly gut hormones, plays a crucial role in metabolic regulation, offering promising targets for intervention.
This review aims to synthesize current knowledge on gut hormone-based therapies for metabolic disorders, focusing on their mechanisms of action and therapeutic potential.
Gut hormones, including GLP-1, GIP, PYY, ghrelin, and oxyntomodulin, orchestrate complex physiological responses to nutrient intake, influencing insulin secretion, appetite, and energy expenditure. Recent advancements in incretin-based therapies, particularly GLP-1 receptor agonists and dual GLP-1/GIP agonists, have shown remarkable efficacy in improving glycemic control and promoting weight loss. These therapies exploit the synergistic actions of multiple gut hormones, offering a more comprehensive approach to metabolic regulation. Emerging research on PYY analogs and ghrelin antagonists further expands the therapeutic landscape. However, challenges remain in optimizing delivery methods, ensuring long-term efficacy, and mitigating potential side effects.
Gut hormone-based therapies represent a paradigm shift in the management of metabolic disorders. By harnessing the intricate signaling networks of the gut-brain axis, these innovative approaches offer the potential for more effective and targeted interventions in obesity and type 2 diabetes, paving the way for personalized treatment strategies in metabolic medicine. |
| format | Article |
| id | doaj-art-8e6815fcb0db4e0b8c5e2071ca09bdcc |
| institution | Kabale University |
| issn | 2008-6792 2345-2250 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Diabetes and Obesity |
| spelling | doaj-art-8e6815fcb0db4e0b8c5e2071ca09bdcc2025-08-20T03:25:11ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity2008-67922345-22502025-05-01172130140Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic SyndromeTamer A. Addissouky0 Department of Biochemistry, Science Faculty, AL-Mustaqbal University, 51001, Hillah, Babylon, Iraq. New burg El-Arab Hospital, Ministry of Health, Alexandria, Egypt. Department of Chemistry, Science Faculty, Menoufia University, Menoufia, Egypt. American Society for Clinical Pathology (ASCP), Chicago, USA. Metabolic disorders, including obesity and type 2 diabetes, have reached epidemic proportions globally, necessitating novel therapeutic approaches. The gut-brain axis, particularly gut hormones, plays a crucial role in metabolic regulation, offering promising targets for intervention. This review aims to synthesize current knowledge on gut hormone-based therapies for metabolic disorders, focusing on their mechanisms of action and therapeutic potential. Gut hormones, including GLP-1, GIP, PYY, ghrelin, and oxyntomodulin, orchestrate complex physiological responses to nutrient intake, influencing insulin secretion, appetite, and energy expenditure. Recent advancements in incretin-based therapies, particularly GLP-1 receptor agonists and dual GLP-1/GIP agonists, have shown remarkable efficacy in improving glycemic control and promoting weight loss. These therapies exploit the synergistic actions of multiple gut hormones, offering a more comprehensive approach to metabolic regulation. Emerging research on PYY analogs and ghrelin antagonists further expands the therapeutic landscape. However, challenges remain in optimizing delivery methods, ensuring long-term efficacy, and mitigating potential side effects. Gut hormone-based therapies represent a paradigm shift in the management of metabolic disorders. By harnessing the intricate signaling networks of the gut-brain axis, these innovative approaches offer the potential for more effective and targeted interventions in obesity and type 2 diabetes, paving the way for personalized treatment strategies in metabolic medicine.http://ijdo.ssu.ac.ir/article-1-955-en.pdfgut-brain axisincretin mimeticsmetabolic syndromeglp-1/gip co-agonistsenteroendocrine signaling |
| spellingShingle | Tamer A. Addissouky Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic Syndrome Iranian Journal of Diabetes and Obesity gut-brain axis incretin mimetics metabolic syndrome glp-1/gip co-agonists enteroendocrine signaling |
| title | Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic Syndrome |
| title_full | Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic Syndrome |
| title_fullStr | Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic Syndrome |
| title_full_unstemmed | Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic Syndrome |
| title_short | Orchestrating Metabolic Homeostasis: The Role of Gut Hormones in Next-Generation Therapies for Metabolic Syndrome |
| title_sort | orchestrating metabolic homeostasis the role of gut hormones in next generation therapies for metabolic syndrome |
| topic | gut-brain axis incretin mimetics metabolic syndrome glp-1/gip co-agonists enteroendocrine signaling |
| url | http://ijdo.ssu.ac.ir/article-1-955-en.pdf |
| work_keys_str_mv | AT tameraaddissouky orchestratingmetabolichomeostasistheroleofguthormonesinnextgenerationtherapiesformetabolicsyndrome |