Conservative management of Oral Submucous Fibrosis in early and intermediate stage
Aims & objective: To evaluate the efficacy of combined intralesional injection of Hyaloronidase and Triamcinolone with third molar removal in early and intermediate stage (Stage II & III) of Oral Submucous Fibrosis (OSMF) for improvement in mouth opening and hypersensitivity to food....
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| Format: | Article |
| Language: | English |
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Elsevier
2018-05-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221242681730009X |
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| author | Sachin Rai Vidya Rattan Akshat Gupta Praveen Kumar |
| author_facet | Sachin Rai Vidya Rattan Akshat Gupta Praveen Kumar |
| author_sort | Sachin Rai |
| collection | DOAJ |
| description | Aims & objective: To evaluate the efficacy of combined intralesional injection of Hyaloronidase and Triamcinolone with third molar removal in early and intermediate stage (Stage II & III) of Oral Submucous Fibrosis (OSMF) for improvement in mouth opening and hypersensitivity to food. Study design: 48 patients in stage II & III OSMF were selected for the study. All the third molars were extracted in each patient followed by 6–8 doses of combined intralesional injection of Hyaloronidase and triamcinolone at 10 days interval targeting the fibrotic bands. Mouth opening and improvement in hypersensitivity to food was noted by numerical grading. The patients were followed for one year at regular intervals. The data was expressed as mean ± SD, and a probability (p) value of <0.05 was considered significant. Results: The initial mouth opening in Stage II patients (n = 27) was 30 ± 3.0 mm and in Stage III patients (n = 21) was 19 ± 3.5 mm and the increase in mouth opening at the end of treatment was 11.3 ± 1.9 mm and 10.2 ± 2.3 mm respectively. The mean improvement in hypersensitivity to food in both the groups was 2.9 and 2.2 respectively. Conclusion: There is significant improvement in grade II patients in mouth opening and hypersensitivity to food. Grade III patients show variable improvement or no improvement wherein surgery becomes the only option. Third molar extraction helps in reducing inflammation and fibrosis in the retromolar region thus easing in mouth opening. This combined approach for moderately staged OSMF can be proposed as a viable conservative modality. |
| format | Article |
| id | doaj-art-8e6614e9dd7745499c6f09f71874ccaa |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2018-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-8e6614e9dd7745499c6f09f71874ccaa2024-11-23T06:27:19ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682018-05-01828688Conservative management of Oral Submucous Fibrosis in early and intermediate stageSachin Rai0Vidya Rattan1Akshat Gupta2Praveen Kumar3Corresponding author.; Unit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaUnit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaUnit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaUnit of Oral & Maxillofacial Surgery, Oral Health Sciences Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaAims & objective: To evaluate the efficacy of combined intralesional injection of Hyaloronidase and Triamcinolone with third molar removal in early and intermediate stage (Stage II & III) of Oral Submucous Fibrosis (OSMF) for improvement in mouth opening and hypersensitivity to food. Study design: 48 patients in stage II & III OSMF were selected for the study. All the third molars were extracted in each patient followed by 6–8 doses of combined intralesional injection of Hyaloronidase and triamcinolone at 10 days interval targeting the fibrotic bands. Mouth opening and improvement in hypersensitivity to food was noted by numerical grading. The patients were followed for one year at regular intervals. The data was expressed as mean ± SD, and a probability (p) value of <0.05 was considered significant. Results: The initial mouth opening in Stage II patients (n = 27) was 30 ± 3.0 mm and in Stage III patients (n = 21) was 19 ± 3.5 mm and the increase in mouth opening at the end of treatment was 11.3 ± 1.9 mm and 10.2 ± 2.3 mm respectively. The mean improvement in hypersensitivity to food in both the groups was 2.9 and 2.2 respectively. Conclusion: There is significant improvement in grade II patients in mouth opening and hypersensitivity to food. Grade III patients show variable improvement or no improvement wherein surgery becomes the only option. Third molar extraction helps in reducing inflammation and fibrosis in the retromolar region thus easing in mouth opening. This combined approach for moderately staged OSMF can be proposed as a viable conservative modality.http://www.sciencedirect.com/science/article/pii/S221242681730009XThird molarHyaluronidaseTriamcinoloneOral Submucous Fibrosis |
| spellingShingle | Sachin Rai Vidya Rattan Akshat Gupta Praveen Kumar Conservative management of Oral Submucous Fibrosis in early and intermediate stage Journal of Oral Biology and Craniofacial Research Third molar Hyaluronidase Triamcinolone Oral Submucous Fibrosis |
| title | Conservative management of Oral Submucous Fibrosis in early and intermediate stage |
| title_full | Conservative management of Oral Submucous Fibrosis in early and intermediate stage |
| title_fullStr | Conservative management of Oral Submucous Fibrosis in early and intermediate stage |
| title_full_unstemmed | Conservative management of Oral Submucous Fibrosis in early and intermediate stage |
| title_short | Conservative management of Oral Submucous Fibrosis in early and intermediate stage |
| title_sort | conservative management of oral submucous fibrosis in early and intermediate stage |
| topic | Third molar Hyaluronidase Triamcinolone Oral Submucous Fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S221242681730009X |
| work_keys_str_mv | AT sachinrai conservativemanagementoforalsubmucousfibrosisinearlyandintermediatestage AT vidyarattan conservativemanagementoforalsubmucousfibrosisinearlyandintermediatestage AT akshatgupta conservativemanagementoforalsubmucousfibrosisinearlyandintermediatestage AT praveenkumar conservativemanagementoforalsubmucousfibrosisinearlyandintermediatestage |