Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand
Abstract Background Most real-world data on CGRP mAbs have been published from high-income countries such as the USA, Western countries, Japan, Korea, and Singapore. However, data from low- and middle-income countries in Southeast Asia is lacking. This is the first real-world study from Thailand to...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-09-01
|
| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-024-01859-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571459407446016 |
|---|---|
| author | Prakit Anukoolwittaya Akarin Hiransuthikul Thanakit Pongpitakmetha Sekh Thanprasertsuk Wanakorn Rattanawong |
| author_facet | Prakit Anukoolwittaya Akarin Hiransuthikul Thanakit Pongpitakmetha Sekh Thanprasertsuk Wanakorn Rattanawong |
| author_sort | Prakit Anukoolwittaya |
| collection | DOAJ |
| description | Abstract Background Most real-world data on CGRP mAbs have been published from high-income countries such as the USA, Western countries, Japan, Korea, and Singapore. However, data from low- and middle-income countries in Southeast Asia is lacking. This is the first real-world study from Thailand to describe the efficacy of CGRP mAbs therapy in migraine patients and to analyze the response trends between episodic migraine and chronic migraine. Methods We conducted a single-center, real-world retrospective chart review study with an observation period of 6 months after CGRP mAbs initiation. We aim to compare treatment responses to CGRP mAbs between EM and CM patients. Results A total of 47 Thai patients were enrolled (median [IQR] age 37.2 [28.6–50.4] years; 85.1%F, 44.7% EM; 70.2% galcanezumab). There was no difference in baseline characteristics and migraine disability assessment (MIDAS) between EM and CM. The overall ≥ 30%, ≥ 50%, and ≥ 70% monthly migraine day reduction rates at 6 months were 89.0%, 71.6%, and 58.5% with higher responders in EM. There was a significant decrease in monthly headache days (MHDs) over time (adjusted β = -0.42, p < 0.001) and a significant decrease in MIDAS score over time after the initiation of CGRP mAbs (adjusted β = -1.12, p = 0.003). However, there were no differences between the two diagnoses. There was no significant decrease in the number of abortive medication pills used over time after the initiation of CGRP mAbs. CM had a significantly steeper trend compared to those with EM. Conclusion The first real-world study in Thailand demonstrated that CGRP mAbs therapy had efficacy for migraine treatment, as evidenced by a reduction in MHDs, decreased disability, and reduced use of abortive medications. Additionally, the response pattern to CGRP mAbs therapy was similar between EM and CM in terms of MHDs reduction and MIDAS score improvement. |
| format | Article |
| id | doaj-art-8e64752ba0164aa29ab5d17aa93586a1 |
| institution | Kabale University |
| issn | 1129-2377 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj-art-8e64752ba0164aa29ab5d17aa93586a12025-02-02T12:34:38ZengBMCThe Journal of Headache and Pain1129-23772024-09-0125111110.1186/s10194-024-01859-3Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in ThailandPrakit Anukoolwittaya0Akarin Hiransuthikul1Thanakit Pongpitakmetha2Sekh Thanprasertsuk3Wanakorn Rattanawong4Chulalongkorn Headache and Orofacial Pain (CHOP) Service and Research Group, Chulalongkorn UniversityChulalongkorn Headache and Orofacial Pain (CHOP) Service and Research Group, Chulalongkorn UniversityChulalongkorn Headache and Orofacial Pain (CHOP) Service and Research Group, Chulalongkorn UniversityChulalongkorn Headache and Orofacial Pain (CHOP) Service and Research Group, Chulalongkorn UniversityChulalongkorn Headache and Orofacial Pain (CHOP) Service and Research Group, Chulalongkorn UniversityAbstract Background Most real-world data on CGRP mAbs have been published from high-income countries such as the USA, Western countries, Japan, Korea, and Singapore. However, data from low- and middle-income countries in Southeast Asia is lacking. This is the first real-world study from Thailand to describe the efficacy of CGRP mAbs therapy in migraine patients and to analyze the response trends between episodic migraine and chronic migraine. Methods We conducted a single-center, real-world retrospective chart review study with an observation period of 6 months after CGRP mAbs initiation. We aim to compare treatment responses to CGRP mAbs between EM and CM patients. Results A total of 47 Thai patients were enrolled (median [IQR] age 37.2 [28.6–50.4] years; 85.1%F, 44.7% EM; 70.2% galcanezumab). There was no difference in baseline characteristics and migraine disability assessment (MIDAS) between EM and CM. The overall ≥ 30%, ≥ 50%, and ≥ 70% monthly migraine day reduction rates at 6 months were 89.0%, 71.6%, and 58.5% with higher responders in EM. There was a significant decrease in monthly headache days (MHDs) over time (adjusted β = -0.42, p < 0.001) and a significant decrease in MIDAS score over time after the initiation of CGRP mAbs (adjusted β = -1.12, p = 0.003). However, there were no differences between the two diagnoses. There was no significant decrease in the number of abortive medication pills used over time after the initiation of CGRP mAbs. CM had a significantly steeper trend compared to those with EM. Conclusion The first real-world study in Thailand demonstrated that CGRP mAbs therapy had efficacy for migraine treatment, as evidenced by a reduction in MHDs, decreased disability, and reduced use of abortive medications. Additionally, the response pattern to CGRP mAbs therapy was similar between EM and CM in terms of MHDs reduction and MIDAS score improvement.https://doi.org/10.1186/s10194-024-01859-3CGRP mAbsMigraineTreatment responseReal-world dataLow-middle-income countiesThailand |
| spellingShingle | Prakit Anukoolwittaya Akarin Hiransuthikul Thanakit Pongpitakmetha Sekh Thanprasertsuk Wanakorn Rattanawong Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand The Journal of Headache and Pain CGRP mAbs Migraine Treatment response Real-world data Low-middle-income counties Thailand |
| title | Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand |
| title_full | Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand |
| title_fullStr | Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand |
| title_full_unstemmed | Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand |
| title_short | Filling the data gap on CGRP mAb therapy in low- to middle-income countries in Southeast Asia: insights from a real-world study in Thailand |
| title_sort | filling the data gap on cgrp mab therapy in low to middle income countries in southeast asia insights from a real world study in thailand |
| topic | CGRP mAbs Migraine Treatment response Real-world data Low-middle-income counties Thailand |
| url | https://doi.org/10.1186/s10194-024-01859-3 |
| work_keys_str_mv | AT prakitanukoolwittaya fillingthedatagaponcgrpmabtherapyinlowtomiddleincomecountriesinsoutheastasiainsightsfromarealworldstudyinthailand AT akarinhiransuthikul fillingthedatagaponcgrpmabtherapyinlowtomiddleincomecountriesinsoutheastasiainsightsfromarealworldstudyinthailand AT thanakitpongpitakmetha fillingthedatagaponcgrpmabtherapyinlowtomiddleincomecountriesinsoutheastasiainsightsfromarealworldstudyinthailand AT sekhthanprasertsuk fillingthedatagaponcgrpmabtherapyinlowtomiddleincomecountriesinsoutheastasiainsightsfromarealworldstudyinthailand AT wanakornrattanawong fillingthedatagaponcgrpmabtherapyinlowtomiddleincomecountriesinsoutheastasiainsightsfromarealworldstudyinthailand |