Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure
Abstract Aims Limited evidence exists regarding the outcomes of cancer patients hospitalized with new onset acute heart failure (AHF). We assessed the in‐hospital mortality and 1 year outcomes of cancer patients admitted for new onset AHF, taking into account both past and active cancer status as we...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.14907 |
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| author | Giancarlo Marenzi Daniela Cardinale Nicola Cosentino Filippo Trombara Paolo Poggio Olivia Leoni Francesco Bortolan Marta Resta Claudia Lucci Nicolò Capra Alice Bonomi Piergiuseppe Agostoni |
| author_facet | Giancarlo Marenzi Daniela Cardinale Nicola Cosentino Filippo Trombara Paolo Poggio Olivia Leoni Francesco Bortolan Marta Resta Claudia Lucci Nicolò Capra Alice Bonomi Piergiuseppe Agostoni |
| author_sort | Giancarlo Marenzi |
| collection | DOAJ |
| description | Abstract Aims Limited evidence exists regarding the outcomes of cancer patients hospitalized with new onset acute heart failure (AHF). We assessed the in‐hospital mortality and 1 year outcomes of cancer patients admitted for new onset AHF, taking into account both past and active cancer status as well as cancer site. Methods We examined administrative data of adult patients hospitalized with a first episode of AHF from 2003 to 2018 in Lombardy, Italy. Patients were categorized based on their cancer history. The primary endpoint was in‐hospital mortality with secondary endpoints including 1 year all‐cause mortality and 1 year re‐hospitalization for AHF. Results Among 283 144 patients AHF hospitalizations, 55 145 (19%) involved patients with a history of cancer (60% past cancer, 40% active cancer). Both in‐hospital and 1 year mortality rates were higher among cancer patients compared with those without (9.3% vs. 6.4% and 34.9% vs. 22.3%, respectively; P < 0.0001). After adjustment, cancer patients exhibited increased risk of in‐hospital mortality [odds ratio (OR) 1.40; 99% confidence interval (CI) 1.34–1.46] and 1 year mortality (HR 1.35; 99% CI 1.32–1.39), particularly among those with lung cancer. Patients with active and past cancer had a similar in‐hospital mortality risk (OR 0.99; 99% CI 0.91–1.07) while 1 year mortality risk was higher among those with active cancer (HR 1.26; 99% CI 1.21–1.31). Conclusions Cancer is a prevalent comorbidity in patients hospitalized with new onset AHF, and it is associated with a poorer prognosis. Mortality risk appears to vary based on cancer status and type. |
| format | Article |
| id | doaj-art-8e60051e09f44e279df9d320248fb2e7 |
| institution | DOAJ |
| issn | 2055-5822 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj-art-8e60051e09f44e279df9d320248fb2e72025-08-20T03:17:13ZengWileyESC Heart Failure2055-58222025-02-0112155456310.1002/ehf2.14907Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failureGiancarlo Marenzi0Daniela Cardinale1Nicola Cosentino2Filippo Trombara3Paolo Poggio4Olivia Leoni5Francesco Bortolan6Marta Resta7Claudia Lucci8Nicolò Capra9Alice Bonomi10Piergiuseppe Agostoni11Centro Cardiologico Monzino, I.R.C.C.S. Milan ItalyCardio‐Oncology Unit European Institute of Oncology, I.R.C.C.S. Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyRegional Epidemiological Observatory, Lombardy Region Milan ItalyRegional Epidemiological Observatory, Lombardy Region Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyCentro Cardiologico Monzino, I.R.C.C.S. Milan ItalyAbstract Aims Limited evidence exists regarding the outcomes of cancer patients hospitalized with new onset acute heart failure (AHF). We assessed the in‐hospital mortality and 1 year outcomes of cancer patients admitted for new onset AHF, taking into account both past and active cancer status as well as cancer site. Methods We examined administrative data of adult patients hospitalized with a first episode of AHF from 2003 to 2018 in Lombardy, Italy. Patients were categorized based on their cancer history. The primary endpoint was in‐hospital mortality with secondary endpoints including 1 year all‐cause mortality and 1 year re‐hospitalization for AHF. Results Among 283 144 patients AHF hospitalizations, 55 145 (19%) involved patients with a history of cancer (60% past cancer, 40% active cancer). Both in‐hospital and 1 year mortality rates were higher among cancer patients compared with those without (9.3% vs. 6.4% and 34.9% vs. 22.3%, respectively; P < 0.0001). After adjustment, cancer patients exhibited increased risk of in‐hospital mortality [odds ratio (OR) 1.40; 99% confidence interval (CI) 1.34–1.46] and 1 year mortality (HR 1.35; 99% CI 1.32–1.39), particularly among those with lung cancer. Patients with active and past cancer had a similar in‐hospital mortality risk (OR 0.99; 99% CI 0.91–1.07) while 1 year mortality risk was higher among those with active cancer (HR 1.26; 99% CI 1.21–1.31). Conclusions Cancer is a prevalent comorbidity in patients hospitalized with new onset AHF, and it is associated with a poorer prognosis. Mortality risk appears to vary based on cancer status and type.https://doi.org/10.1002/ehf2.14907acute heart failureadministrative databasecancerin‐hospital mortality1 year mortality |
| spellingShingle | Giancarlo Marenzi Daniela Cardinale Nicola Cosentino Filippo Trombara Paolo Poggio Olivia Leoni Francesco Bortolan Marta Resta Claudia Lucci Nicolò Capra Alice Bonomi Piergiuseppe Agostoni Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure ESC Heart Failure acute heart failure administrative database cancer in‐hospital mortality 1 year mortality |
| title | Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure |
| title_full | Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure |
| title_fullStr | Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure |
| title_full_unstemmed | Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure |
| title_short | Characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure |
| title_sort | characteristics and outcomes of patients with cancer hospitalized with new onset acute heart failure |
| topic | acute heart failure administrative database cancer in‐hospital mortality 1 year mortality |
| url | https://doi.org/10.1002/ehf2.14907 |
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