Reversing cardiac hypertrophy and heart failure using a cardiac targeting peptide linked to miRNA106a

Reversing cardiac hypertrophy and heart failure using a cardiac targeting peptide linked to miRNA106a

Abstract Background One in five adults aged 40 will develop heart failure (HF) during their lifetime. Risk factors (e.g., hypertension, diabetes mellitus, coronary artery disease, etc.) lead to structural and functional changes in cardiomyocytes, resulting in HF. At the cellular level, these changes...

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Main Authors: Ming Lu, Siqi Cai, Kyle Korolowicz, Claire Deng, Kaan Taskintuna, Gerard Ahern, Raymond B. Yurko, Kazi R. Islam, Bryn Schoonover, Jack B. Lopuszynski, Hongkun Wang, Maliha Zahid, G. Ian Gallicano
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Clinical and Translational Medicine
Subjects:
cardiac targeting peptide
heart failure
miRNA therapy
NF‐kB
Online Access:https://doi.org/10.1002/ctm2.70432
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