Von Willebrand disease (VWD) and pregnancy: a comprehensive overview
Abstract Von Willebrand disease (VWD) is a hereditary bleeding disorder characterized by a quantitative or qualitative deficiency of von Willebrand factor (VWF). Pregnancy significantly impacts hemostasis, leading to a hypercoagulable state. However, women with VWD experience unique challenges due t...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Thrombosis Journal |
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| Online Access: | https://doi.org/10.1186/s12959-025-00727-7 |
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| author | Hamed Soleimani Samarkhazan Mohammad Navid khaksari Ali Rahmati Mahsa Loran Esfahani Amin Solouki Mojtaba Aghaei |
| author_facet | Hamed Soleimani Samarkhazan Mohammad Navid khaksari Ali Rahmati Mahsa Loran Esfahani Amin Solouki Mojtaba Aghaei |
| author_sort | Hamed Soleimani Samarkhazan |
| collection | DOAJ |
| description | Abstract Von Willebrand disease (VWD) is a hereditary bleeding disorder characterized by a quantitative or qualitative deficiency of von Willebrand factor (VWF). Pregnancy significantly impacts hemostasis, leading to a hypercoagulable state. However, women with VWD experience unique challenges due to the interplay between pregnancy-related hormonal changes and VWF deficiencies. This review delves into the intricate relationship between VWD and pregnancy. We explored the physiological changes that occur during pregnancy, including hormonal fluctuations, hemodilution, and alterations in platelet–VWF interactions. We discuss how these changes can exacerbate bleeding tendencies in women with VWD, particularly during childbirth and the postpartum period. This review highlights the increased risk of postpartum hemorrhage (PPH) in women with VWD and the potential for severe maternal morbidity and mortality. We examine the various types of VWD and their specific implications for pregnancy outcomes. Additionally, we discuss the challenges associated with diagnosing and managing VWD during pregnancy, as well as the importance of prenatal counseling and careful monitoring. The management of VWD during pregnancy involves a multidisciplinary approach, including the use of prophylactic treatments, such as desmopressin and tranexamic acid, as well as factor replacement therapy when necessary. Careful planning of delivery, including the choice of delivery mode and the timing of interventions, is essential to minimize bleeding complications. By understanding the complexities of VWD during pregnancy and implementing appropriate management strategies, healthcare providers can significantly improve the outcomes for women with VWD and their offspring. |
| format | Article |
| id | doaj-art-8e54ad3822374e8fa0829bcdb27626a0 |
| institution | DOAJ |
| issn | 1477-9560 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj-art-8e54ad3822374e8fa0829bcdb27626a02025-08-20T02:55:23ZengBMCThrombosis Journal1477-95602025-04-0123111110.1186/s12959-025-00727-7Von Willebrand disease (VWD) and pregnancy: a comprehensive overviewHamed Soleimani Samarkhazan0Mohammad Navid khaksari1Ali Rahmati2Mahsa Loran Esfahani3Amin Solouki4Mojtaba Aghaei5Student Research Committee, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical SciencesDepartment of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical SciencesDepartment of Medical Laboratory Sciences, School of Allied Medicine, Kermanshah University of Medical SciencesDepartment of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical SciencesStudent Research Committee, Ahvaz Jundishapur University of Medical SciencesAbstract Von Willebrand disease (VWD) is a hereditary bleeding disorder characterized by a quantitative or qualitative deficiency of von Willebrand factor (VWF). Pregnancy significantly impacts hemostasis, leading to a hypercoagulable state. However, women with VWD experience unique challenges due to the interplay between pregnancy-related hormonal changes and VWF deficiencies. This review delves into the intricate relationship between VWD and pregnancy. We explored the physiological changes that occur during pregnancy, including hormonal fluctuations, hemodilution, and alterations in platelet–VWF interactions. We discuss how these changes can exacerbate bleeding tendencies in women with VWD, particularly during childbirth and the postpartum period. This review highlights the increased risk of postpartum hemorrhage (PPH) in women with VWD and the potential for severe maternal morbidity and mortality. We examine the various types of VWD and their specific implications for pregnancy outcomes. Additionally, we discuss the challenges associated with diagnosing and managing VWD during pregnancy, as well as the importance of prenatal counseling and careful monitoring. The management of VWD during pregnancy involves a multidisciplinary approach, including the use of prophylactic treatments, such as desmopressin and tranexamic acid, as well as factor replacement therapy when necessary. Careful planning of delivery, including the choice of delivery mode and the timing of interventions, is essential to minimize bleeding complications. By understanding the complexities of VWD during pregnancy and implementing appropriate management strategies, healthcare providers can significantly improve the outcomes for women with VWD and their offspring.https://doi.org/10.1186/s12959-025-00727-7Von Willebrand diseasePregnancyHemostasisPlateletPostpartum hemorrhageBleeding disorders |
| spellingShingle | Hamed Soleimani Samarkhazan Mohammad Navid khaksari Ali Rahmati Mahsa Loran Esfahani Amin Solouki Mojtaba Aghaei Von Willebrand disease (VWD) and pregnancy: a comprehensive overview Thrombosis Journal Von Willebrand disease Pregnancy Hemostasis Platelet Postpartum hemorrhage Bleeding disorders |
| title | Von Willebrand disease (VWD) and pregnancy: a comprehensive overview |
| title_full | Von Willebrand disease (VWD) and pregnancy: a comprehensive overview |
| title_fullStr | Von Willebrand disease (VWD) and pregnancy: a comprehensive overview |
| title_full_unstemmed | Von Willebrand disease (VWD) and pregnancy: a comprehensive overview |
| title_short | Von Willebrand disease (VWD) and pregnancy: a comprehensive overview |
| title_sort | von willebrand disease vwd and pregnancy a comprehensive overview |
| topic | Von Willebrand disease Pregnancy Hemostasis Platelet Postpartum hemorrhage Bleeding disorders |
| url | https://doi.org/10.1186/s12959-025-00727-7 |
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