Simultaneous optical recording of action potentials and calcium transients in cardiac single cells differentiated from type 1 CPVT-iPS cells

Simultaneous optical recording of action potentials and calcium transients in cardiac single cells differentiated from type 1 CPVT-iPS cells

Numerous reports investigating channelopathies, including Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT), have successfully reproduced using cardiomyocytes (CMs) differentiated from human induced pluripotent stem cells (hiPSCs). However, the relationship between action potentials (AP)...

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Bibliographic Details
Main Authors: Tadashi Takaki, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Physiology
Subjects:
FluoVolt
membrane potential dye
Calbryte 590
calcium transient
catecholaminergic polymorphic ventricular tachycardia
induced pluripotent stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1579815/full
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