Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics

Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics

IntroductionDysbiosis is a key mechanism in inflammatory bowel disease (IBD) pathophysiology. Previous microbiota studies in IBD generally have involved patients treated with immunosuppressive agents, which can affect the results. We aimed to elucidate the fecal microbiota composition in newly diagn...

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Main Authors: Macarena Orejudo, Manuel J. Gómez, Sabino Riestra, Montserrat Rivero, Ana Gutiérrez, Iago Rodríguez-Lago, Luis Fernández-Salazar, Daniel Ceballos, José Manuel Benítez, Mariam Aguas, Iria Bastón-Rey, Fernando Bermejo, María José Casanova, Rufo H. Lorente-Poyatos, Yolanda Ber, Daniel Ginard, María Esteve, Ruth de Francisco, María José García, Rubén Francés, Ainhoa Rodríguez, Noelia Alcaide Suárez, Elena Guerra del Río, Pilar Soto, Pilar Nos, Manuel Barreiro-de Acosta, Iván Guerra, Daniel Hervías Cruz, Manuel Domínguez Cajal, Vanesa Royo, Montserrat Aceituno, Laila Aldars-García, Ana Garre, Cristina Ramírez, Irene Soleto, Ina Schuppe-Koistinen, Lars Engstrand, Montse Baldán-Martín, Fátima Sánchez-Cabo, Javier P. Gisbert, María Chaparro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
inflammatory bowel disease
Crohn’s disease
ulcerative colitis
microbiota
metagenomics
shotgun
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1595884/full
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