Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History
Bipolar disorder is a chronic psychiatric condition typically managed using mood stabilizers such as valproic acid, lithium, and atypical antipsychotics, the former which is absorbed in the gastrointestinal tract. This case report presents the challenges encountered in managing bipolar disorder in a...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2024/1426930 |
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| _version_ | 1849403375220686848 |
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| author | James Kwok Janeline Wong Kye Kim |
| author_facet | James Kwok Janeline Wong Kye Kim |
| author_sort | James Kwok |
| collection | DOAJ |
| description | Bipolar disorder is a chronic psychiatric condition typically managed using mood stabilizers such as valproic acid, lithium, and atypical antipsychotics, the former which is absorbed in the gastrointestinal tract. This case report presents the challenges encountered in managing bipolar disorder in a patient with a history of extensive gastrointestinal (GI) issues. The patient was initially treated with lithium but experienced adverse effects, prompting a switch to valproic acid (VPA) tablets. However, due to ongoing GI problems unrelated to her medication and to help improve tolerability, the patient underwent multiple medication formulation changes, including Depakote delayed release tablets, Depakene liquid, and Depakote sprinkle capsules. However, the patient’s VPA levels decreased below therapeutic levels after the formulation changes despite medication compliance. This case highlights the importance of considering GI issues in optimization of a treatment plan for patients with bipolar disorder. |
| format | Article |
| id | doaj-art-8e461cc22e044477a724865c74cfb7a2 |
| institution | Kabale University |
| issn | 2090-6838 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-8e461cc22e044477a724865c74cfb7a22025-08-20T03:37:17ZengWileyCase Reports in Psychiatry2090-68382024-01-01202410.1155/2024/1426930Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal HistoryJames Kwok0Janeline Wong1Kye Kim2Virginia Tech Carilion School of MedicineVirginia Tech Carilion School of MedicineVirginia Tech Carilion School of MedicineBipolar disorder is a chronic psychiatric condition typically managed using mood stabilizers such as valproic acid, lithium, and atypical antipsychotics, the former which is absorbed in the gastrointestinal tract. This case report presents the challenges encountered in managing bipolar disorder in a patient with a history of extensive gastrointestinal (GI) issues. The patient was initially treated with lithium but experienced adverse effects, prompting a switch to valproic acid (VPA) tablets. However, due to ongoing GI problems unrelated to her medication and to help improve tolerability, the patient underwent multiple medication formulation changes, including Depakote delayed release tablets, Depakene liquid, and Depakote sprinkle capsules. However, the patient’s VPA levels decreased below therapeutic levels after the formulation changes despite medication compliance. This case highlights the importance of considering GI issues in optimization of a treatment plan for patients with bipolar disorder.http://dx.doi.org/10.1155/2024/1426930 |
| spellingShingle | James Kwok Janeline Wong Kye Kim Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History Case Reports in Psychiatry |
| title | Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History |
| title_full | Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History |
| title_fullStr | Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History |
| title_full_unstemmed | Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History |
| title_short | Management Challenges and Potential Malabsorption of Valproic Acid in a Patient with Bipolar Disorder and Gastrointestinal History |
| title_sort | management challenges and potential malabsorption of valproic acid in a patient with bipolar disorder and gastrointestinal history |
| url | http://dx.doi.org/10.1155/2024/1426930 |
| work_keys_str_mv | AT jameskwok managementchallengesandpotentialmalabsorptionofvalproicacidinapatientwithbipolardisorderandgastrointestinalhistory AT janelinewong managementchallengesandpotentialmalabsorptionofvalproicacidinapatientwithbipolardisorderandgastrointestinalhistory AT kyekim managementchallengesandpotentialmalabsorptionofvalproicacidinapatientwithbipolardisorderandgastrointestinalhistory |