Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis
ObjectiveTo evaluate the diagnostic value of 3.0T high-resolution magnetic resonance imaging (3.0T HR-MRI), ultrasound imaging, and GATA3 protein expression in breast cancer (BC) and their prognostic implications.MethodsA retrospective analysis of 143 BC patients was conducted. All patients underwen...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1587243/full |
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| author | Yang Bai Ting Xie Xiangyang Mo Yong Luo Man Chen |
| author_facet | Yang Bai Ting Xie Xiangyang Mo Yong Luo Man Chen |
| author_sort | Yang Bai |
| collection | DOAJ |
| description | ObjectiveTo evaluate the diagnostic value of 3.0T high-resolution magnetic resonance imaging (3.0T HR-MRI), ultrasound imaging, and GATA3 protein expression in breast cancer (BC) and their prognostic implications.MethodsA retrospective analysis of 143 BC patients was conducted. All patients underwent preoperative 3.0T HR-MRI and ultrasound examinations. Diffusion tensor imaging (DTI) parameters, including mean diffusivity (MD), fractional anisotropy (FA), radial diffusivity (Dr), and axial diffusivity (Da), were assessed. Ultrasound features such as tumor morphology, vascularity, and posterior acoustic characteristics were analyzed. Immunohistochemistry was performed to detect GATA3 expression, and correlations with imaging parameters and prognosis were evaluated.ResultsGATA3 expression was significantly associated with BC pathological subtypes ( x2= 26.59, P < 0.0001). Compared with the GATA3-negative group, GATA3-positive tumors exhibited lower FA but higher MD, Dr, and Da values (P < 0.05), suggesting more preserved tissue structure. Ultrasound analysis showed that GATA3-positive tumors had less vascularity, posterior attenuation, and irregular margins (P < 0.05). Poor prognosis was associated with higher FA and lower MD, Dr, and Da values (P < 0.0001), as well as more aggressive ultrasound features. ROC analysis demonstrated superior prognostic performance when combining GATA3 expression, MRI, and ultrasound parameters (AUC = 0.9695, sensitivity = 83.54%, specificity = 96.88%).Conclusion3.0T HR-MRI and ultrasound provide complementary insights into BC characteristics. GATA3 expression is associated with better prognosis, and their combined analysis enhances diagnostic accuracy and prognostic evaluation. |
| format | Article |
| id | doaj-art-8e43383bd1b54afea4718e2546f7e7f2 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-8e43383bd1b54afea4718e2546f7e7f22025-08-20T04:00:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15872431587243Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysisYang Bai0Ting Xie1Xiangyang Mo2Yong Luo3Man Chen4The Second Affiliated Hospital, Department of Ultrasound Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe Second Affiliated Hospital, Department of Emergency, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe Affiliated Nanhua Hospital, Department of Emergency, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe Second Affiliated Hospital, Department of Emergency, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaThe Second Affiliated Hospital, Department of Ultrasound Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, ChinaObjectiveTo evaluate the diagnostic value of 3.0T high-resolution magnetic resonance imaging (3.0T HR-MRI), ultrasound imaging, and GATA3 protein expression in breast cancer (BC) and their prognostic implications.MethodsA retrospective analysis of 143 BC patients was conducted. All patients underwent preoperative 3.0T HR-MRI and ultrasound examinations. Diffusion tensor imaging (DTI) parameters, including mean diffusivity (MD), fractional anisotropy (FA), radial diffusivity (Dr), and axial diffusivity (Da), were assessed. Ultrasound features such as tumor morphology, vascularity, and posterior acoustic characteristics were analyzed. Immunohistochemistry was performed to detect GATA3 expression, and correlations with imaging parameters and prognosis were evaluated.ResultsGATA3 expression was significantly associated with BC pathological subtypes ( x2= 26.59, P < 0.0001). Compared with the GATA3-negative group, GATA3-positive tumors exhibited lower FA but higher MD, Dr, and Da values (P < 0.05), suggesting more preserved tissue structure. Ultrasound analysis showed that GATA3-positive tumors had less vascularity, posterior attenuation, and irregular margins (P < 0.05). Poor prognosis was associated with higher FA and lower MD, Dr, and Da values (P < 0.0001), as well as more aggressive ultrasound features. ROC analysis demonstrated superior prognostic performance when combining GATA3 expression, MRI, and ultrasound parameters (AUC = 0.9695, sensitivity = 83.54%, specificity = 96.88%).Conclusion3.0T HR-MRI and ultrasound provide complementary insights into BC characteristics. GATA3 expression is associated with better prognosis, and their combined analysis enhances diagnostic accuracy and prognostic evaluation.https://www.frontiersin.org/articles/10.3389/fonc.2025.1587243/fullhigh-resolution magnetic resonance imagingultrasoundGATA3breast cancerdiffusion tensor imaging |
| spellingShingle | Yang Bai Ting Xie Xiangyang Mo Yong Luo Man Chen Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis Frontiers in Oncology high-resolution magnetic resonance imaging ultrasound GATA3 breast cancer diffusion tensor imaging |
| title | Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis |
| title_full | Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis |
| title_fullStr | Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis |
| title_full_unstemmed | Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis |
| title_short | Multidimensional evaluation of 3.0T HR-MRI, ultrasound imaging, and GATA3 protein expression in breast cancer, and their prognostic analysis |
| title_sort | multidimensional evaluation of 3 0t hr mri ultrasound imaging and gata3 protein expression in breast cancer and their prognostic analysis |
| topic | high-resolution magnetic resonance imaging ultrasound GATA3 breast cancer diffusion tensor imaging |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1587243/full |
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