Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α

Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α

Estrogen deficiency is considered the most important cause of postmenopausal osteoporosis. However, the underlying mechanism is still not completely understood. In this study, progranulin (PGRN) was isolated as a key regulator of bone mineral density in postmenopausal women through high throughput p...

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Bibliographic Details
Main Authors: Guangfei Li, Aifei Wang, Wei Tang, Wenyu Fu, Qingyun Tian, Jinlong Jian, Michal Lata, Aubryanna Hettinghouse, Yuanjing Ding, Jianlu Wei, Xiangli Zhao, Mingyong Wang, Qirong Dong, Chuanju Liu, Youjia Xu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-01-01
Series:Genes and Diseases
Subjects:
Estrogen receptor α
Osteoclastogenesis
Postmenopausal osteoporosis
Progranulin
Ubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304224000187
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