Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery
Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocul...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2015/535092 |
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| author | Pin Chen Xin Wang Yan Dong Xiaohong Hu |
| author_facet | Pin Chen Xin Wang Yan Dong Xiaohong Hu |
| author_sort | Pin Chen |
| collection | DOAJ |
| description | Hydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work. Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, since β-CD showed good drug delivery property. The properties such as the contact angle and transparency varied a little with the deposition of poly(CM-β-CD)/PLL multilayer. Orfloxacin and puerarin were loaded into multilayer during the self-assembly procedure by two methods, which were tracked by the largest drug absorbance of UV spectrum. The loaded drug amount by incorporating drugs into poly(CM-β-CD) solution was larger than that by incorporating drugs into PLL solution. The loaded drug in the multilayer could gradually be released from multilayer in some period either for orfloxacin or for puerarin. The drug release behavior was influenced by drug loading method and pH value of released medium. Moreover, the balanced released drug amount by incorporating drugs into poly(CM-β-CD) solution is much smaller than that by incorporating drugs into PLL solution. |
| format | Article |
| id | doaj-art-8e30e1860af34769b441b288c71767f5 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-8e30e1860af34769b441b288c71767f52025-02-03T05:45:42ZengWileyInternational Journal of Polymer Science1687-94221687-94302015-01-01201510.1155/2015/535092535092Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug DeliveryPin Chen0Xin Wang1Yan Dong2Xiaohong Hu3School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaSchool of Material Engineering, Jinling Institute of Technology, Nanjing 211169, ChinaHydrogel is a kind of attractive drug carriers because of its good biocompatibility and transparency. But traditional hydrogel showed some restrictions in its application in ocular drug delivery. A simple surface modification technique based on layer-by-layer (LbL) self-assembled multilayer for ocular drug delivery was developed in this work. Polycarboxymethyl-β-cyclodextrin (poly(CM-β-CD))/poly-l-lysine (PLL) multilayer film was designed and constructed for ocular drug delivery, since β-CD showed good drug delivery property. The properties such as the contact angle and transparency varied a little with the deposition of poly(CM-β-CD)/PLL multilayer. Orfloxacin and puerarin were loaded into multilayer during the self-assembly procedure by two methods, which were tracked by the largest drug absorbance of UV spectrum. The loaded drug amount by incorporating drugs into poly(CM-β-CD) solution was larger than that by incorporating drugs into PLL solution. The loaded drug in the multilayer could gradually be released from multilayer in some period either for orfloxacin or for puerarin. The drug release behavior was influenced by drug loading method and pH value of released medium. Moreover, the balanced released drug amount by incorporating drugs into poly(CM-β-CD) solution is much smaller than that by incorporating drugs into PLL solution.http://dx.doi.org/10.1155/2015/535092 |
| spellingShingle | Pin Chen Xin Wang Yan Dong Xiaohong Hu Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery International Journal of Polymer Science |
| title | Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery |
| title_full | Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery |
| title_fullStr | Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery |
| title_full_unstemmed | Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery |
| title_short | Development of a Layer-by-Layer Assembled Film on Hydrogel for Ocular Drug Delivery |
| title_sort | development of a layer by layer assembled film on hydrogel for ocular drug delivery |
| url | http://dx.doi.org/10.1155/2015/535092 |
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