Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population
Abstract Background Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated an association between the atherogenic index of plasma (AIP) and insulin resistance, there remains a scarcity of large cohort studies investigat...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-025-02605-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract Background Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated an association between the atherogenic index of plasma (AIP) and insulin resistance, there remains a scarcity of large cohort studies investigating the association between AIP and the long-term risk of T2D in the general population. This study aims to investigate the potential association between AIP and the long-term risk of T2D in individuals with normal fasting plasma glucose levels. Methods This retrospective cohort study included 15,453 participants. The AIP was calculated using the formula log [triglyceride (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. Cox proportional hazard regression models were employed to assess the association between AIP and T2D risk. The nonlinear association was examined using a restricted cubic spline (RCS) model. Results During an average follow-up period of 6.05 years, 373 participants developed T2D. After adjusting for confounding factors, elevated AIP was independently associated with an increased risk of developing T2D (HR 1.763, 95%CI 1.210–2.568, P = 0.003). The RCS analysis revealed a J-shaped association between AIP and T2D risk, with a sharp increase in risk when AIP levels exceeded − 0.268. Moreover, time-dependent receiver operating characteristic analysis consistently demonstrated a moderate predictability of AIP for new-onset T2D within 1 to 12 years. Conclusion The AIP exhibits a J-shaped association with the risk of developing T2D. Therefore, maintaining AIP levels below a certain threshold (-0.268) might help prevent the onset of T2D. Graphical abstract |
|---|---|
| ISSN: | 1475-2840 |