Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease
Malondialdehyde (MDA) is a naturally occurring organic compound produced as a byproduct of lipid peroxidation. It serves as one of the most widely recognized biomarkers for oxidative stress. Elevated levels of MDA have been observed in patients with inflammatory bowel disease (IBD), suggesting its i...
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MDPI AG
2024-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/10/1171 |
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| author | Nayra Merino de Paz Marta Carrillo-Palau Alejandro Hernández-Camba Pedro Abreu-González Antonia de Vera-González Alejandra González-Delgado Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_facet | Nayra Merino de Paz Marta Carrillo-Palau Alejandro Hernández-Camba Pedro Abreu-González Antonia de Vera-González Alejandra González-Delgado Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro |
| author_sort | Nayra Merino de Paz |
| collection | DOAJ |
| description | Malondialdehyde (MDA) is a naturally occurring organic compound produced as a byproduct of lipid peroxidation. It serves as one of the most widely recognized biomarkers for oxidative stress. Elevated levels of MDA have been observed in patients with inflammatory bowel disease (IBD), suggesting its involvement in the pathogenesis and progression of the disease. In this study, we analyzed MDA levels within a well-characterized and extensive cohort of IBD patients. Our objective was to investigate the association between MDA levels and disease characteristics in this population. This is a cross-sectional study that encompassed 197 patients with IBD. Multivariable linear regression analysis was performed to study the relationship between disease characteristics and circulating MDA. MDA was significantly associated with male sex in IBD patients but not with other demographic characteristics or classic cardiovascular risk factors. Regarding disease features such as phenotype or activity indices, their relationship with MDA was scarce. Several lipid profile molecules showed a significant association with MDA levels after multivariable analysis. Similarly, the liver fibrosis-4 index and hepatic elastography values were significantly related to higher MDA levels after adjusting for covariates. In conclusion, the sources of elevated MDA in IBD are primarily linked to lipid profile abnormalities and liver disease. |
| format | Article |
| id | doaj-art-8e2a0fd3a80c47a49a3c8e21328215db |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-8e2a0fd3a80c47a49a3c8e21328215db2025-08-20T02:11:08ZengMDPI AGAntioxidants2076-39212024-09-011310117110.3390/antiox13101171Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel DiseaseNayra Merino de Paz0Marta Carrillo-Palau1Alejandro Hernández-Camba2Pedro Abreu-González3Antonia de Vera-González4Alejandra González-Delgado5Candelaria Martín-González6Miguel Á. González-Gay7Iván Ferraz-Amaro8Division of Dermatology, Dermamedicin Clínicas, 38004 Santa Cruz de Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, SpainDivision of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, SpainUnit of Physiology, Department of Basic Medical Sciences, University of La Laguna, 38200 Tenerife, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38200 Tenerife, SpainDivision of Central Laboratory, Hospital Universitario de Canarias, 38200 Tenerife, SpainDepartment of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, SpainDivision of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, SpainDepartment of Internal Medicine, Universidad de La Laguna (ULL), 38200 Tenerife, SpainMalondialdehyde (MDA) is a naturally occurring organic compound produced as a byproduct of lipid peroxidation. It serves as one of the most widely recognized biomarkers for oxidative stress. Elevated levels of MDA have been observed in patients with inflammatory bowel disease (IBD), suggesting its involvement in the pathogenesis and progression of the disease. In this study, we analyzed MDA levels within a well-characterized and extensive cohort of IBD patients. Our objective was to investigate the association between MDA levels and disease characteristics in this population. This is a cross-sectional study that encompassed 197 patients with IBD. Multivariable linear regression analysis was performed to study the relationship between disease characteristics and circulating MDA. MDA was significantly associated with male sex in IBD patients but not with other demographic characteristics or classic cardiovascular risk factors. Regarding disease features such as phenotype or activity indices, their relationship with MDA was scarce. Several lipid profile molecules showed a significant association with MDA levels after multivariable analysis. Similarly, the liver fibrosis-4 index and hepatic elastography values were significantly related to higher MDA levels after adjusting for covariates. In conclusion, the sources of elevated MDA in IBD are primarily linked to lipid profile abnormalities and liver disease.https://www.mdpi.com/2076-3921/13/10/1171ulcerative colitisCrohn’s diseaseinflammatory bowel diseasemalondialdehyde serum levelsoxidative stress |
| spellingShingle | Nayra Merino de Paz Marta Carrillo-Palau Alejandro Hernández-Camba Pedro Abreu-González Antonia de Vera-González Alejandra González-Delgado Candelaria Martín-González Miguel Á. González-Gay Iván Ferraz-Amaro Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease Antioxidants ulcerative colitis Crohn’s disease inflammatory bowel disease malondialdehyde serum levels oxidative stress |
| title | Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease |
| title_full | Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease |
| title_fullStr | Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease |
| title_short | Association of Serum Malondialdehyde Levels with Lipid Profile and Liver Function in Patients with Inflammatory Bowel Disease |
| title_sort | association of serum malondialdehyde levels with lipid profile and liver function in patients with inflammatory bowel disease |
| topic | ulcerative colitis Crohn’s disease inflammatory bowel disease malondialdehyde serum levels oxidative stress |
| url | https://www.mdpi.com/2076-3921/13/10/1171 |
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