Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression
Anxiety disorders (AnxDs) are highly prevalent throughout the lifespan, with detrimental effects on daily-life functioning, somatic health, and quality of life. An emerging perspective suggested that AnxDs may be associated with accelerated aging. In this paper, we explored the association between A...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/8457612 |
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| author | Giampaolo Perna Giuseppe Iannone Alessandra Alciati Daniela Caldirola |
| author_facet | Giampaolo Perna Giuseppe Iannone Alessandra Alciati Daniela Caldirola |
| author_sort | Giampaolo Perna |
| collection | DOAJ |
| description | Anxiety disorders (AnxDs) are highly prevalent throughout the lifespan, with detrimental effects on daily-life functioning, somatic health, and quality of life. An emerging perspective suggested that AnxDs may be associated with accelerated aging. In this paper, we explored the association between AnxDs and hallmarks of accelerated aging, with a specific focus on neuroprogression. We reviewed animal and human findings that suggest an overlap between processes of impaired neurogenesis, neurodegeneration, structural, functional, molecular, and cellular modifications in AnxDs, and aging. Although this research is at an early stage, our review suggests a link between anxiety and accelerated aging across multiple processes involved in neuroprogression. Brain structural and functional changes that accompany normal aging were more pronounced in subjects with AnxDs than in coevals without AnxDs, including reduced grey matter density, white matter alterations, impaired functional connectivity of large-scale brain networks, and poorer cognitive performance. Similarly, molecular correlates of brain aging, including telomere shortening, Aβ accumulation, and immune-inflammatory and oxidative/nitrosative stress, were overrepresented in anxious subjects. No conclusions about causality or directionality between anxiety and accelerated aging can be drawn. Potential mechanisms of this association, limitations of the current research, and implications for treatments and future studies are discussed. |
| format | Article |
| id | doaj-art-8e29c0b55df949b2b572dda1395e735c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8e29c0b55df949b2b572dda1395e735c2025-02-03T06:01:29ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/84576128457612Are Anxiety Disorders Associated with Accelerated Aging? A Focus on NeuroprogressionGiampaolo Perna0Giuseppe Iannone1Alessandra Alciati2Daniela Caldirola3Department of Clinical Neurosciences, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, 22032 Como, ItalyDepartment of Clinical Neurosciences, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, 22032 Como, ItalyDepartment of Clinical Neurosciences, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, 22032 Como, ItalyDepartment of Clinical Neurosciences, Hermanas Hospitalarias, FoRiPsi, Villa San Benedetto Menni, Albese con Cassano, 22032 Como, ItalyAnxiety disorders (AnxDs) are highly prevalent throughout the lifespan, with detrimental effects on daily-life functioning, somatic health, and quality of life. An emerging perspective suggested that AnxDs may be associated with accelerated aging. In this paper, we explored the association between AnxDs and hallmarks of accelerated aging, with a specific focus on neuroprogression. We reviewed animal and human findings that suggest an overlap between processes of impaired neurogenesis, neurodegeneration, structural, functional, molecular, and cellular modifications in AnxDs, and aging. Although this research is at an early stage, our review suggests a link between anxiety and accelerated aging across multiple processes involved in neuroprogression. Brain structural and functional changes that accompany normal aging were more pronounced in subjects with AnxDs than in coevals without AnxDs, including reduced grey matter density, white matter alterations, impaired functional connectivity of large-scale brain networks, and poorer cognitive performance. Similarly, molecular correlates of brain aging, including telomere shortening, Aβ accumulation, and immune-inflammatory and oxidative/nitrosative stress, were overrepresented in anxious subjects. No conclusions about causality or directionality between anxiety and accelerated aging can be drawn. Potential mechanisms of this association, limitations of the current research, and implications for treatments and future studies are discussed.http://dx.doi.org/10.1155/2016/8457612 |
| spellingShingle | Giampaolo Perna Giuseppe Iannone Alessandra Alciati Daniela Caldirola Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression Neural Plasticity |
| title | Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression |
| title_full | Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression |
| title_fullStr | Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression |
| title_full_unstemmed | Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression |
| title_short | Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression |
| title_sort | are anxiety disorders associated with accelerated aging a focus on neuroprogression |
| url | http://dx.doi.org/10.1155/2016/8457612 |
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