The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy
Neurological disorders represent a major global health concern owing to their intricate pathological processes. Ferroptosis, defined as a form of cell death that is reliant on iron, has been closely linked to various neurological conditions. The fundamental process underlying ferroptosis is defined...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1591417/full |
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| author | Chenyu Xie Chenyu Xie Nan Wu Jiaojiao Guo Liangliang Ma Congcong Zhang |
| author_facet | Chenyu Xie Chenyu Xie Nan Wu Jiaojiao Guo Liangliang Ma Congcong Zhang |
| author_sort | Chenyu Xie |
| collection | DOAJ |
| description | Neurological disorders represent a major global health concern owing to their intricate pathological processes. Ferroptosis, defined as a form of cell death that is reliant on iron, has been closely linked to various neurological conditions. The fundamental process underlying ferroptosis is defined by the excessive buildup of iron ions, which initiates lipid peroxidation processes leading to cellular demise. Neurons, as highly metabolically active cells, are susceptible to oxidative stress, and imbalances in iron metabolism can directly initiate the ferroptosis process. In neurodegenerative disorders like Alzheimer’s disease and Parkinson’s disease, ferroptosis driven by iron accumulation represents a fundamental pathological connection. Although the connection between ferroptosis and neurological diseases is clear, clinical application still faces challenges, such as precise regulation of iron metabolism, development of specific drugs, and assessment of efficacy. The limited comprehension of the ferroptosis mechanism hinders the development of personalized treatment approaches. Consequently, subsequent investigations must tackle these obstacles to facilitate the clinical application of ferroptosis-associated therapies in neurological disorders. This article provides a comprehensive overview of the most recent advancements regarding the underlying mechanisms of ferroptosis. Subsequently, the study investigates the mechanistic contributions of ferroptosis within the nervous system. In conclusion, we evaluate and deliberate on targeted therapeutic strategies associated with ferroptosis and neurological disorders. |
| format | Article |
| id | doaj-art-8e2111044f3a478fbc76df10bdc0ff10 |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-8e2111044f3a478fbc76df10bdc0ff102025-08-20T03:09:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-05-011910.3389/fnins.2025.15914171591417The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapyChenyu Xie0Chenyu Xie1Nan Wu2Jiaojiao Guo3Liangliang Ma4Congcong Zhang5Department of Rehabilitation, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaDepartment of Rehabilitation, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, ChinaRehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou, Henan, ChinaNeurological disorders represent a major global health concern owing to their intricate pathological processes. Ferroptosis, defined as a form of cell death that is reliant on iron, has been closely linked to various neurological conditions. The fundamental process underlying ferroptosis is defined by the excessive buildup of iron ions, which initiates lipid peroxidation processes leading to cellular demise. Neurons, as highly metabolically active cells, are susceptible to oxidative stress, and imbalances in iron metabolism can directly initiate the ferroptosis process. In neurodegenerative disorders like Alzheimer’s disease and Parkinson’s disease, ferroptosis driven by iron accumulation represents a fundamental pathological connection. Although the connection between ferroptosis and neurological diseases is clear, clinical application still faces challenges, such as precise regulation of iron metabolism, development of specific drugs, and assessment of efficacy. The limited comprehension of the ferroptosis mechanism hinders the development of personalized treatment approaches. Consequently, subsequent investigations must tackle these obstacles to facilitate the clinical application of ferroptosis-associated therapies in neurological disorders. This article provides a comprehensive overview of the most recent advancements regarding the underlying mechanisms of ferroptosis. Subsequently, the study investigates the mechanistic contributions of ferroptosis within the nervous system. In conclusion, we evaluate and deliberate on targeted therapeutic strategies associated with ferroptosis and neurological disorders.https://www.frontiersin.org/articles/10.3389/fnins.2025.1591417/fullferroptosisneurological diseasescell deathresearch progressmedication therapy |
| spellingShingle | Chenyu Xie Chenyu Xie Nan Wu Jiaojiao Guo Liangliang Ma Congcong Zhang The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy Frontiers in Neuroscience ferroptosis neurological diseases cell death research progress medication therapy |
| title | The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy |
| title_full | The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy |
| title_fullStr | The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy |
| title_full_unstemmed | The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy |
| title_short | The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy |
| title_sort | key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy |
| topic | ferroptosis neurological diseases cell death research progress medication therapy |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1591417/full |
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