Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production
Investigating Moringa oleifera (M. oleifera)’ is potential as a livestock feed additive, this review explores its nutritional and phytochemical profiles and its mechanistic roles, specifically focusing on its immunomodulatory and antioxidant properties. M. oleifera is a rich source of diverse bioact...
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| Format: | Article |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1615349/full |
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| author | Raza Mohai Ud Din Salwa Eman Muhammad Hammad Zafar Zhang Chong Ahmed A. Saleh Ahmed A. Saleh Hosameldeen Mohamed Husien Hosameldeen Mohamed Husien Mengzhi Wang Mengzhi Wang |
| author_facet | Raza Mohai Ud Din Salwa Eman Muhammad Hammad Zafar Zhang Chong Ahmed A. Saleh Ahmed A. Saleh Hosameldeen Mohamed Husien Hosameldeen Mohamed Husien Mengzhi Wang Mengzhi Wang |
| author_sort | Raza Mohai Ud Din |
| collection | DOAJ |
| description | Investigating Moringa oleifera (M. oleifera)’ is potential as a livestock feed additive, this review explores its nutritional and phytochemical profiles and its mechanistic roles, specifically focusing on its immunomodulatory and antioxidant properties. M. oleifera is a rich source of diverse bioactive compounds, including polyphenols, alkaloids, terpenoids, flavonoids (e.g., quercetin, kaempferol), saponins, and tocopherols. These compounds exert significant immunomodulatory effects by modulating cytokine production and immune cell activity. Notably, Moringa-derived arabinogalactans (water-soluble polysaccharides comprising arabinose and galactose monomers) activate the gut-associated immune system through beneficial modulation of gut microbiota composition, increasing genera such as Muribaculaceae and Lactobacillus. The immunomodulatory activity is mediated via multiple pathways, including the promotion of anti-inflammatory cytokine secretion (e.g., IL-10) and the inhibition of pro-inflammatory enzymes [e.g., cyclooxygenase-2 (COX-2)]. Furthermore, M. oleifera exhibits potent antioxidant capabilities by enhancing endogenous defenses, neutralizing reactive oxygen species, and mitigating oxidative stress-induced tissue damage. These findings underscore M. oleifera is potential to enhance disease resistance and immune function in animals, advocating for its strategic incorporation into sustainable animal nutrition practices. |
| format | Article |
| id | doaj-art-8e1e7d2b4d5e49d6a24337aa0dcb3c6e |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-8e1e7d2b4d5e49d6a24337aa0dcb3c6e2025-08-20T03:47:20ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-06-011210.3389/fnut.2025.16153491615349Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock productionRaza Mohai Ud Din0Salwa Eman1Muhammad Hammad Zafar2Zhang Chong3Ahmed A. Saleh4Ahmed A. Saleh5Hosameldeen Mohamed Husien6Hosameldeen Mohamed Husien7Mengzhi Wang8Mengzhi Wang9Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, ChinaLaboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, ChinaLaboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, ChinaLaboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Animal and Fish Production, Faculty of Agriculture (Al-Shatby), Alexandria University, Alexandria, EgyptLaboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, ChinaCollege of Veterinary Medicine, Albutana University, Rufaa, SudanLaboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, ChinaState Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural Reclamation Sciences, Shihezi, Xinjiang, ChinaInvestigating Moringa oleifera (M. oleifera)’ is potential as a livestock feed additive, this review explores its nutritional and phytochemical profiles and its mechanistic roles, specifically focusing on its immunomodulatory and antioxidant properties. M. oleifera is a rich source of diverse bioactive compounds, including polyphenols, alkaloids, terpenoids, flavonoids (e.g., quercetin, kaempferol), saponins, and tocopherols. These compounds exert significant immunomodulatory effects by modulating cytokine production and immune cell activity. Notably, Moringa-derived arabinogalactans (water-soluble polysaccharides comprising arabinose and galactose monomers) activate the gut-associated immune system through beneficial modulation of gut microbiota composition, increasing genera such as Muribaculaceae and Lactobacillus. The immunomodulatory activity is mediated via multiple pathways, including the promotion of anti-inflammatory cytokine secretion (e.g., IL-10) and the inhibition of pro-inflammatory enzymes [e.g., cyclooxygenase-2 (COX-2)]. Furthermore, M. oleifera exhibits potent antioxidant capabilities by enhancing endogenous defenses, neutralizing reactive oxygen species, and mitigating oxidative stress-induced tissue damage. These findings underscore M. oleifera is potential to enhance disease resistance and immune function in animals, advocating for its strategic incorporation into sustainable animal nutrition practices.https://www.frontiersin.org/articles/10.3389/fnut.2025.1615349/fullMoringa oleiferanutritional profileimmunomodulatory mechanismanimalfeed additive |
| spellingShingle | Raza Mohai Ud Din Salwa Eman Muhammad Hammad Zafar Zhang Chong Ahmed A. Saleh Ahmed A. Saleh Hosameldeen Mohamed Husien Hosameldeen Mohamed Husien Mengzhi Wang Mengzhi Wang Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production Frontiers in Nutrition Moringa oleifera nutritional profile immunomodulatory mechanism animal feed additive |
| title | Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production |
| title_full | Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production |
| title_fullStr | Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production |
| title_full_unstemmed | Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production |
| title_short | Moringa oleifera as a multifunctional feed additive: synergistic nutritional and immunomodulatory mechanisms in livestock production |
| title_sort | moringa oleifera as a multifunctional feed additive synergistic nutritional and immunomodulatory mechanisms in livestock production |
| topic | Moringa oleifera nutritional profile immunomodulatory mechanism animal feed additive |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1615349/full |
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