The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction
Purpose. Acupuncture is an effective therapy for Internet addiction (IA). However, the underlying mechanisms of acupuncture in relieving compulsive Internet use remain unknown. Neuroimaging studies have demonstrated the role of the ventral striatum (VS) in the progress of IA; hence, the aim of this...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/7409417 |
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| author | Yang Wang Yun Qin Hui Li Dezhong Yao Bo Sun Zhiliang Li Xin Li Yu Dai Chao Wen Lingrui Zhang Chenchen Zhang Tianmin Zhu Cheng Luo |
| author_facet | Yang Wang Yun Qin Hui Li Dezhong Yao Bo Sun Zhiliang Li Xin Li Yu Dai Chao Wen Lingrui Zhang Chenchen Zhang Tianmin Zhu Cheng Luo |
| author_sort | Yang Wang |
| collection | DOAJ |
| description | Purpose. Acupuncture is an effective therapy for Internet addiction (IA). However, the underlying mechanisms of acupuncture in relieving compulsive Internet use remain unknown. Neuroimaging studies have demonstrated the role of the ventral striatum (VS) in the progress of IA; hence, the aim of this study was to explore the effects of acupuncture on the resting-state functional connectivity (rsFC) and relevant network of VS in IA. Methods. Twenty-seven IA individuals and 30 demographically matched healthy control subjects (HCs) were recruited in this study. We acquired the functional magnetic resonance imaging (fMRI) data in IA subjects before and after 40 days of acupuncture treatment. Seed-to-voxel and ROI-to-ROI analyses were applied to detect the rsFC alterations of the VS and related network in IA subjects and to investigate the modulation effect of acupuncture on the rsFC. Results. Compared with HCs, IA subjects exhibited enhanced rsFC of the right ventral rostral putamen (VRP) with the left orbitofrontal cortex (OFC), premotor cortex (PMC), cerebellum, and right ventromedial prefrontal cortex (vmPFC). In the network including these five ROIs, IA also showed increased ROI-to-ROI rsFC. Using a paired t-test in IA subjects before and after 40 days of acupuncture, the increased ROI-to-ROI rsFC was decreased (normalized to HC) with acupuncture, including the rsFC of the right VRP with the left OFC, PMC, and cerebellum, and the rsFC of the left cerebellum with the left OFC, PMC, and right vmPFC. Furthermore, the change in rsFC strength between the right VRP and left cerebellum in IA individuals was found positively correlated with the Internet craving alleviation after acupuncture. Conclusions. These findings verified the modulation effect of acupuncture on functional connectivity of reward and habit systems related to the VS in IA individuals, which might partly represent the underlying mechanisms of acupuncture on IA. |
| format | Article |
| id | doaj-art-8e1ba3524bc94371900f3411a44bd856 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-8e1ba3524bc94371900f3411a44bd8562025-02-03T00:58:46ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/74094177409417The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet AddictionYang Wang0Yun Qin1Hui Li2Dezhong Yao3Bo Sun4Zhiliang Li5Xin Li6Yu Dai7Chao Wen8Lingrui Zhang9Chenchen Zhang10Tianmin Zhu11Cheng Luo12School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, Chengdu University, Chengdu, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Rehabilitation, Zigong Fifth People’s Hospital, Zigong, ChinaDepartment of Medicine, Leshan Vocational and Technical College, Leshan, ChinaDepartment of Rehabilitation, TCM Hospital of Longquanyi District, Chengdu, ChinaSchool of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaKey Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaPurpose. Acupuncture is an effective therapy for Internet addiction (IA). However, the underlying mechanisms of acupuncture in relieving compulsive Internet use remain unknown. Neuroimaging studies have demonstrated the role of the ventral striatum (VS) in the progress of IA; hence, the aim of this study was to explore the effects of acupuncture on the resting-state functional connectivity (rsFC) and relevant network of VS in IA. Methods. Twenty-seven IA individuals and 30 demographically matched healthy control subjects (HCs) were recruited in this study. We acquired the functional magnetic resonance imaging (fMRI) data in IA subjects before and after 40 days of acupuncture treatment. Seed-to-voxel and ROI-to-ROI analyses were applied to detect the rsFC alterations of the VS and related network in IA subjects and to investigate the modulation effect of acupuncture on the rsFC. Results. Compared with HCs, IA subjects exhibited enhanced rsFC of the right ventral rostral putamen (VRP) with the left orbitofrontal cortex (OFC), premotor cortex (PMC), cerebellum, and right ventromedial prefrontal cortex (vmPFC). In the network including these five ROIs, IA also showed increased ROI-to-ROI rsFC. Using a paired t-test in IA subjects before and after 40 days of acupuncture, the increased ROI-to-ROI rsFC was decreased (normalized to HC) with acupuncture, including the rsFC of the right VRP with the left OFC, PMC, and cerebellum, and the rsFC of the left cerebellum with the left OFC, PMC, and right vmPFC. Furthermore, the change in rsFC strength between the right VRP and left cerebellum in IA individuals was found positively correlated with the Internet craving alleviation after acupuncture. Conclusions. These findings verified the modulation effect of acupuncture on functional connectivity of reward and habit systems related to the VS in IA individuals, which might partly represent the underlying mechanisms of acupuncture on IA.http://dx.doi.org/10.1155/2020/7409417 |
| spellingShingle | Yang Wang Yun Qin Hui Li Dezhong Yao Bo Sun Zhiliang Li Xin Li Yu Dai Chao Wen Lingrui Zhang Chenchen Zhang Tianmin Zhu Cheng Luo The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction Neural Plasticity |
| title | The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction |
| title_full | The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction |
| title_fullStr | The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction |
| title_full_unstemmed | The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction |
| title_short | The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction |
| title_sort | modulation of reward and habit systems by acupuncture in adolescents with internet addiction |
| url | http://dx.doi.org/10.1155/2020/7409417 |
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