BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.

BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin.

Hemojuvelin (Hjv), a member of the repulsive-guidance molecule (RGM) family, upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Mammalian models have identified furin, neogenin, and matriptase-2 a...

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Main Authors: Yann Gibert, Victoria J Lattanzi, Aileen W Zhen, Lea Vedder, Frédéric Brunet, Sarah A Faasse, Jodie L Babitt, Herbert Y Lin, Matthias Hammerschmidt, Paula G Fraenkel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014553&type=printable
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