Immunogenic cell death: A new strategy to enhancing cancer immunotherapy
Immunogenic cell death (ICD) is a distinct type of stress-induced regulated cell death that can lead to adaptive immune responses and the establishment of immunological memory. ICD exhibits both similarities and differences when compared to apoptosis and other non-apoptotic forms of regulated cell d...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2437918 |
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| author | Lei Dou Yu Fang Huiyuan Yang Guo Ai Na Shen |
| author_facet | Lei Dou Yu Fang Huiyuan Yang Guo Ai Na Shen |
| author_sort | Lei Dou |
| collection | DOAJ |
| description | Immunogenic cell death (ICD) is a distinct type of stress-induced regulated cell death that can lead to adaptive immune responses and the establishment of immunological memory. ICD exhibits both similarities and differences when compared to apoptosis and other non-apoptotic forms of regulated cell death (RCD). The interplay between ICD-mediated immunosurveillance against cancer and the ability of cancer cells to evade ICD influences the host-tumor immunological interaction. Consequently, the restoration of ICD and the development of effective strategies to induce ICD have emerged as crucial considerations in the treatment of cancer within the context of immunotherapy. To enhance comprehension of ICD in the setting of cancer, this paper examines the interconnected responsive pathways associated with ICD, the corresponding biomarkers indicative of ICD, and the mechanisms through which tumors subvert ICD. Additionally, this review explores strategies for reinstating ICD and the therapeutic potential of harnessing ICD in cancer immunotherapy. |
| format | Article |
| id | doaj-art-8e14c55b9fe147789f3eedc58b79e63e |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-8e14c55b9fe147789f3eedc58b79e63e2025-08-20T02:16:48ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2437918Immunogenic cell death: A new strategy to enhancing cancer immunotherapyLei Dou0Yu Fang1Huiyuan Yang2Guo Ai3Na Shen4Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaIntensive Care Unit, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaImmunogenic cell death (ICD) is a distinct type of stress-induced regulated cell death that can lead to adaptive immune responses and the establishment of immunological memory. ICD exhibits both similarities and differences when compared to apoptosis and other non-apoptotic forms of regulated cell death (RCD). The interplay between ICD-mediated immunosurveillance against cancer and the ability of cancer cells to evade ICD influences the host-tumor immunological interaction. Consequently, the restoration of ICD and the development of effective strategies to induce ICD have emerged as crucial considerations in the treatment of cancer within the context of immunotherapy. To enhance comprehension of ICD in the setting of cancer, this paper examines the interconnected responsive pathways associated with ICD, the corresponding biomarkers indicative of ICD, and the mechanisms through which tumors subvert ICD. Additionally, this review explores strategies for reinstating ICD and the therapeutic potential of harnessing ICD in cancer immunotherapy.https://www.tandfonline.com/doi/10.1080/21645515.2024.2437918Cancerimmunogenic cell deathcell stressimmunotherapynanoparticle |
| spellingShingle | Lei Dou Yu Fang Huiyuan Yang Guo Ai Na Shen Immunogenic cell death: A new strategy to enhancing cancer immunotherapy Human Vaccines & Immunotherapeutics Cancer immunogenic cell death cell stress immunotherapy nanoparticle |
| title | Immunogenic cell death: A new strategy to enhancing cancer immunotherapy |
| title_full | Immunogenic cell death: A new strategy to enhancing cancer immunotherapy |
| title_fullStr | Immunogenic cell death: A new strategy to enhancing cancer immunotherapy |
| title_full_unstemmed | Immunogenic cell death: A new strategy to enhancing cancer immunotherapy |
| title_short | Immunogenic cell death: A new strategy to enhancing cancer immunotherapy |
| title_sort | immunogenic cell death a new strategy to enhancing cancer immunotherapy |
| topic | Cancer immunogenic cell death cell stress immunotherapy nanoparticle |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2437918 |
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