Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014
PurposeThis study aimed to investigate the association between serum calcium levels and periodontitis in a U.S. adult population, using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2014.MethodData were analyzed from 8,601 participants aged over 30 years, who were cate...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1520639/full |
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| author | Hongliang Cao Min Wang Mengna Duan Song Wang Haiyang Zhang |
| author_facet | Hongliang Cao Min Wang Mengna Duan Song Wang Haiyang Zhang |
| author_sort | Hongliang Cao |
| collection | DOAJ |
| description | PurposeThis study aimed to investigate the association between serum calcium levels and periodontitis in a U.S. adult population, using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2014.MethodData were analyzed from 8,601 participants aged over 30 years, who were categorized based on the presence or absence of periodontitis. Serum calcium levels were measured using standardized NHANES protocols, and periodontitis status was determined through clinical oral examinations. To assess the relationship between calcium levels and periodontitis, multivariate logistic regression models were applied across three levels of adjustment. Additionally, trend tests and subgroup analyses were conducted to explore associations across different demographic and clinical subgroups. A smoothing curve fitting and threshold effect analysis were also performed to examine potential nonlinear relationships.ResultsAfter adjusting multiple covariates, participants in the highest quartile of serum calcium showed an 18% reduced risk of periodontitis compared to those in the lowest quartile (OR = 0.82, 95% CI: 0.71–0.95, p = 0.0083; p for trend = 0.0057). The association remained stable across various subgroups. Smoothing curve fitting indicated a nonlinear negative correlation between calcium levels and periodontitis, though without a significant inflection point at 2.48 mmol/L (p = 0.094).ConclusionElevated serum calcium levels appear to be associated with a lower risk of periodontitis in adults. These findings suggest that adequate calcium intake may play a role in periodontitis prevention, providing valuable insight for clinical guidance on nutritional and preventive strategies in periodontal health. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-8e0e1d1548854f1980cfbcdcf0837cc02025-01-07T06:46:42ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.15206391520639Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014Hongliang Cao0Min Wang1Mengna Duan2Song Wang3Haiyang Zhang4Department of Urology II, The First Hospital of Jilin University, Changchun, ChinaDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, ChinaDepartment of Urology II, The First Hospital of Jilin University, Changchun, ChinaDepartment of Prosthodontics, Hospital of Stomatology, Jilin University, Changchun, ChinaPurposeThis study aimed to investigate the association between serum calcium levels and periodontitis in a U.S. adult population, using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2014.MethodData were analyzed from 8,601 participants aged over 30 years, who were categorized based on the presence or absence of periodontitis. Serum calcium levels were measured using standardized NHANES protocols, and periodontitis status was determined through clinical oral examinations. To assess the relationship between calcium levels and periodontitis, multivariate logistic regression models were applied across three levels of adjustment. Additionally, trend tests and subgroup analyses were conducted to explore associations across different demographic and clinical subgroups. A smoothing curve fitting and threshold effect analysis were also performed to examine potential nonlinear relationships.ResultsAfter adjusting multiple covariates, participants in the highest quartile of serum calcium showed an 18% reduced risk of periodontitis compared to those in the lowest quartile (OR = 0.82, 95% CI: 0.71–0.95, p = 0.0083; p for trend = 0.0057). The association remained stable across various subgroups. Smoothing curve fitting indicated a nonlinear negative correlation between calcium levels and periodontitis, though without a significant inflection point at 2.48 mmol/L (p = 0.094).ConclusionElevated serum calcium levels appear to be associated with a lower risk of periodontitis in adults. These findings suggest that adequate calcium intake may play a role in periodontitis prevention, providing valuable insight for clinical guidance on nutritional and preventive strategies in periodontal health.https://www.frontiersin.org/articles/10.3389/fnut.2024.1520639/fullserum calciumperiodontitisNHANEScross-sectional studyepidemiologynutrition |
| spellingShingle | Hongliang Cao Min Wang Mengna Duan Song Wang Haiyang Zhang Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014 Frontiers in Nutrition serum calcium periodontitis NHANES cross-sectional study epidemiology nutrition |
| title | Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014 |
| title_full | Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014 |
| title_fullStr | Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014 |
| title_full_unstemmed | Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014 |
| title_short | Association of serum calcium level with periodontitis: a cross-sectional study from NHANES 2009–2014 |
| title_sort | association of serum calcium level with periodontitis a cross sectional study from nhanes 2009 2014 |
| topic | serum calcium periodontitis NHANES cross-sectional study epidemiology nutrition |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1520639/full |
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