Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literature
Abstract Myelomatous pleural effusion (MPE) is a rare, often treatment‐resistant complication of multiple myeloma. Intrapleural bortezomib shows promise but lacks standardized dosing. We report a 62‐year‐old woman with MPE treated with 1.3 mg/m2 (2 mg) subcutaneous and 0.975 mg/m2 (1.5 mg) intrapleu...
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Wiley
2024-12-01
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| Online Access: | https://doi.org/10.1002/jha2.998 |
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| author | Yu‐Ming Li Mei‐Hua Tsou Tran‐Der Tan |
| author_facet | Yu‐Ming Li Mei‐Hua Tsou Tran‐Der Tan |
| author_sort | Yu‐Ming Li |
| collection | DOAJ |
| description | Abstract Myelomatous pleural effusion (MPE) is a rare, often treatment‐resistant complication of multiple myeloma. Intrapleural bortezomib shows promise but lacks standardized dosing. We report a 62‐year‐old woman with MPE treated with 1.3 mg/m2 (2 mg) subcutaneous and 0.975 mg/m2 (1.5 mg) intrapleural bortezomib on days 1 and 4. Despite MPE regression, significant toxicity occurred. Adjusted dosing to 0.65 mg/m2 (1 mg) for both routes on days 11 and 14 consolidated the response without side effects. This case demonstrates the feasibility of intrapleural therapy and the importance of cautious dosing. Literature supports equal intrapleural and systemic bortezomib dosing for MPE management. |
| format | Article |
| id | doaj-art-8e0dfbcd6c3b49dab2d0eab5f399f4ea |
| institution | OA Journals |
| issn | 2688-6146 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj-art-8e0dfbcd6c3b49dab2d0eab5f399f4ea2025-08-20T02:36:31ZengWileyeJHaem2688-61462024-12-01561325132910.1002/jha2.998Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literatureYu‐Ming Li0Mei‐Hua Tsou1Tran‐Der Tan2Department of Internal Medicine Koo Foundation Sun Yat‐Sen Cancer Center Taipei TaiwanDepartment of Pathology and Laboratory Medicine Koo Foundation Sun Yat‐Sen Cancer Center Taipei TaiwanDepartment of Hematopoietic Stem Cell Transplantation and Cell Therapy Koo Foundation Sun Yat‐Sen Cancer Center Taipei TaiwanAbstract Myelomatous pleural effusion (MPE) is a rare, often treatment‐resistant complication of multiple myeloma. Intrapleural bortezomib shows promise but lacks standardized dosing. We report a 62‐year‐old woman with MPE treated with 1.3 mg/m2 (2 mg) subcutaneous and 0.975 mg/m2 (1.5 mg) intrapleural bortezomib on days 1 and 4. Despite MPE regression, significant toxicity occurred. Adjusted dosing to 0.65 mg/m2 (1 mg) for both routes on days 11 and 14 consolidated the response without side effects. This case demonstrates the feasibility of intrapleural therapy and the importance of cautious dosing. Literature supports equal intrapleural and systemic bortezomib dosing for MPE management.https://doi.org/10.1002/jha2.998bortezomibcase reportmultiple myelomapleural effusion |
| spellingShingle | Yu‐Ming Li Mei‐Hua Tsou Tran‐Der Tan Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literature eJHaem bortezomib case report multiple myeloma pleural effusion |
| title | Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literature |
| title_full | Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literature |
| title_fullStr | Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literature |
| title_full_unstemmed | Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literature |
| title_short | Dosing strategy of intrapleural bortezomib for myelomatous pleural effusion: A case report and review of literature |
| title_sort | dosing strategy of intrapleural bortezomib for myelomatous pleural effusion a case report and review of literature |
| topic | bortezomib case report multiple myeloma pleural effusion |
| url | https://doi.org/10.1002/jha2.998 |
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