Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital
Introduction: Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide. The purpose of this study was to identify risk factors for bacteremia due to ESBL-producing Escherichia coli in a Turkish hospital. Methodology: We ret...
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The Journal of Infection in Developing Countries
2013-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/2788 |
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| author | Onur Kaya Fusun Zeynep Akcam Ibak Gonen Onur Unal Tennure Ceylan |
| author_facet | Onur Kaya Fusun Zeynep Akcam Ibak Gonen Onur Unal Tennure Ceylan |
| author_sort | Onur Kaya |
| collection | DOAJ |
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Introduction: Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide. The purpose of this study was to identify risk factors for bacteremia due to ESBL-producing Escherichia coli in a Turkish hospital.
Methodology: We retrospectively reviewed the medical records of patients with E. coli bacteremia in a tertiary care centre from January 2007 to October 2011. Data from patients such as demographic features, underlying conditions, and antibiotic exposure were analysed.
Results: A total of 113 patients with bacteremia due to E. coli were included and data from patients with ESBL-producing E. coli (case patients) were compared to those with non-ESBL-producing E. coli (control patients). The frequency of ESBL producers was 38.9% (44/113). Exposure to fluoroquinolones and cephalosporins, history of intra-abdominal surgery intervention, and presence of central venous catheteter and urinary catheteter were more frequently detected among case patients (P < 0.05). Independent risk factors for bacteremia due to ESBL-producing E. coli were exposure to fluoroquinolones (OR 13.39, 95% CI 1.28-140.03) and cephalosporins (OR 3.48, 95% CI 1.03-11.74).
Conclusions: Previous use of fluoroquinolone and cephalosporin in patients with bacteremia caused by E. coli increased the risk for ESBL-producing strains.
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| format | Article |
| id | doaj-art-8e0a986daeca4af4b03e51887a9c828d |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2013-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-8e0a986daeca4af4b03e51887a9c828d2025-08-20T03:48:58ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802013-07-0170710.3855/jidc.2788Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospitalOnur Kaya0Fusun Zeynep Akcam1Ibak Gonen2Onur Unal3Tennure Ceylan4Faculty of Medicine, Suleyman Demirel University, Isparta, TurkeyFaculty of Medicine, Suleyman Demirel University, Isparta, TurkeyFaculty of Medicine, Suleyman Demirel University, Isparta, TurkeyFaculty of Medicine, Suleyman Demirel University, Isparta, TurkeyFaculty of Medicine, Suleyman Demirel University, Isparta, Turkey Introduction: Bloodstream infection caused by extended-spectrum beta-lactamase (ESBL)-producing pathogens has become a serious concern worldwide. The purpose of this study was to identify risk factors for bacteremia due to ESBL-producing Escherichia coli in a Turkish hospital. Methodology: We retrospectively reviewed the medical records of patients with E. coli bacteremia in a tertiary care centre from January 2007 to October 2011. Data from patients such as demographic features, underlying conditions, and antibiotic exposure were analysed. Results: A total of 113 patients with bacteremia due to E. coli were included and data from patients with ESBL-producing E. coli (case patients) were compared to those with non-ESBL-producing E. coli (control patients). The frequency of ESBL producers was 38.9% (44/113). Exposure to fluoroquinolones and cephalosporins, history of intra-abdominal surgery intervention, and presence of central venous catheteter and urinary catheteter were more frequently detected among case patients (P < 0.05). Independent risk factors for bacteremia due to ESBL-producing E. coli were exposure to fluoroquinolones (OR 13.39, 95% CI 1.28-140.03) and cephalosporins (OR 3.48, 95% CI 1.03-11.74). Conclusions: Previous use of fluoroquinolone and cephalosporin in patients with bacteremia caused by E. coli increased the risk for ESBL-producing strains. https://jidc.org/index.php/journal/article/view/2788risk factorsEscherichia colibacteremiaextended-spectrum beta-lactamase |
| spellingShingle | Onur Kaya Fusun Zeynep Akcam Ibak Gonen Onur Unal Tennure Ceylan Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital Journal of Infection in Developing Countries risk factors Escherichia coli bacteremia extended-spectrum beta-lactamase |
| title | Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital |
| title_full | Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital |
| title_fullStr | Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital |
| title_full_unstemmed | Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital |
| title_short | Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing Escherichia coli in a Turkish hospital |
| title_sort | risk factors for bacteremia due to extended spectrum beta lactamase producing escherichia coli in a turkish hospital |
| topic | risk factors Escherichia coli bacteremia extended-spectrum beta-lactamase |
| url | https://jidc.org/index.php/journal/article/view/2788 |
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