Transdermal delivery of antenatal steroids to promote fetal lung maturation: Proof of principle data from sheep and non-human primate models

Transdermal delivery of antenatal steroids to promote fetal lung maturation: Proof of principle data from sheep and non-human primate models

Abstract Background Antenatal steroids (ANS) are routinely administered to women at risk of preterm birth to accelerate fetal lung maturation. Despite extensive clinical use, dosing and route of ANS administration remain unoptimized beyond intramuscular (IM) injection. We aimed to undertake a proof-...

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Main Authors: Sean W. D. Carter, Ayça Altay Benetti, Ryan Tze Liang Sia, Giorgia Pastorin, Erin L. Johnson, Kay Yi Michelle Seah, Haruo Usuda, Hannah R. S. Watson, Yusaku Kumagai, Qin Wei, Xiawen Liu, Roberto Orefice, Marianne Bon, Zubair Amin, Agnihotri Biswas, Tsukasa Takahashi, Noriyoshi Mochii, Yuya Saito, Hideyuki Ikeda, Masatoshi Saito, Mahesh A. Choolani, Sebastián E. Illanes, Matthew W. Kemp
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Medicine
Subjects:
Antenatal corticosteroids
Preterm birth
Transdermal patch
Optimizing route of administration
Fetal lung maturation
Perinatal medicine
Online Access:https://doi.org/10.1186/s12916-025-04267-9
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