Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients
Kağan Tur,1 Aydın Güçlü2 1Ahi Evran University Faculty of Medicine, Internal Medicine Department, Kirsehir, Turkey; 2Ahi Evran University Faculty of Medicine, Nephrology Department, Kirsehir, TurkeyCorrespondence: Kağan Tur, Ahi Evran University Faculty of Medicine,...
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Dove Medical Press
2024-11-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/independent-association-between-malnutrition-inflammation-score-and-c--peer-reviewed-fulltext-article-JIR |
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| author | Tur K Güçlü A |
| author_facet | Tur K Güçlü A |
| author_sort | Tur K |
| collection | DOAJ |
| description | Kağan Tur,1 Aydın Güçlü2 1Ahi Evran University Faculty of Medicine, Internal Medicine Department, Kirsehir, Turkey; 2Ahi Evran University Faculty of Medicine, Nephrology Department, Kirsehir, TurkeyCorrespondence: Kağan Tur, Ahi Evran University Faculty of Medicine, Internal Medicine Department, Kirsehir, Turkey, Tel +90 5057733927, Email kaantur542@gmail.com; kagan.tur@ahievran.edu.trIntroduction: This study aimed to investigate the relationship between the Malnutrition Inflammation Score (MIS) and the C-reactive protein/albumin ratio (CAR) in patients undergoing hemodialysis (HD).Materials and Methods: Sixty-six End-Stage Renal Disease (ESRD) patients on maintenance hemodialysis were recruited for the study. Malnutrition Inflammation Score, biochemical parameters, and C-reactive protein/albumin ratio were analyzed.Results: The mean age of the participants was 56.47 ± 17.3 years. A statistically significant positive correlation was found between the CRP/albumin ratio and MIS ≥ 7 (r = 0.413, p = 0.026), CRP and MIS ≥ 7 (r = 0.388, p = 0.038) and a negative correlation between albumin and MIS (r = − 0.511, p = 0.005). Additionally, MIS was negatively correlated with hemoglobin (r = − 0.412, p = 0.026) and creatinine (r = − 0.568, p = 0.001), while a positive correlation was found between MIS and ferritin (r = 0.584, p = 0.001) for MIS ≥ 7. A multiple regression ANOVA model confirmed a significant association between CAR, CRP, albumin, and MIS (F = 6.432, p = 0.002), with significant contributions from CAR (p = 0.003), albumin (p = 0.008), and CRP (p = 0.003).Conclusion: Our study is the first to show an independent association between CAR and MIS in hemodialysis patients. The CRP/albumin ratio can serve as a valuable indicator of malnutrition in this population, providing a reliable tool for assessing nutritional status.Keywords: malnutrition inflammation score, malnutrition, CRP/albumin ratio, hemodialysis |
| format | Article |
| id | doaj-art-8e0630bd7cbc4ce4be8d2efe596ac90f |
| institution | OA Journals |
| issn | 1178-7031 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-8e0630bd7cbc4ce4be8d2efe596ac90f2025-08-20T02:32:41ZengDove Medical PressJournal of Inflammation Research1178-70312024-11-01Volume 179325933397554Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis PatientsTur KGüçlü AKağan Tur,1 Aydın Güçlü2 1Ahi Evran University Faculty of Medicine, Internal Medicine Department, Kirsehir, Turkey; 2Ahi Evran University Faculty of Medicine, Nephrology Department, Kirsehir, TurkeyCorrespondence: Kağan Tur, Ahi Evran University Faculty of Medicine, Internal Medicine Department, Kirsehir, Turkey, Tel +90 5057733927, Email kaantur542@gmail.com; kagan.tur@ahievran.edu.trIntroduction: This study aimed to investigate the relationship between the Malnutrition Inflammation Score (MIS) and the C-reactive protein/albumin ratio (CAR) in patients undergoing hemodialysis (HD).Materials and Methods: Sixty-six End-Stage Renal Disease (ESRD) patients on maintenance hemodialysis were recruited for the study. Malnutrition Inflammation Score, biochemical parameters, and C-reactive protein/albumin ratio were analyzed.Results: The mean age of the participants was 56.47 ± 17.3 years. A statistically significant positive correlation was found between the CRP/albumin ratio and MIS ≥ 7 (r = 0.413, p = 0.026), CRP and MIS ≥ 7 (r = 0.388, p = 0.038) and a negative correlation between albumin and MIS (r = − 0.511, p = 0.005). Additionally, MIS was negatively correlated with hemoglobin (r = − 0.412, p = 0.026) and creatinine (r = − 0.568, p = 0.001), while a positive correlation was found between MIS and ferritin (r = 0.584, p = 0.001) for MIS ≥ 7. A multiple regression ANOVA model confirmed a significant association between CAR, CRP, albumin, and MIS (F = 6.432, p = 0.002), with significant contributions from CAR (p = 0.003), albumin (p = 0.008), and CRP (p = 0.003).Conclusion: Our study is the first to show an independent association between CAR and MIS in hemodialysis patients. The CRP/albumin ratio can serve as a valuable indicator of malnutrition in this population, providing a reliable tool for assessing nutritional status.Keywords: malnutrition inflammation score, malnutrition, CRP/albumin ratio, hemodialysishttps://www.dovepress.com/independent-association-between-malnutrition-inflammation-score-and-c--peer-reviewed-fulltext-article-JIRmalnutrition inflammation scoremalnutritioncrp/albumin ratiohemodialysis |
| spellingShingle | Tur K Güçlü A Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients Journal of Inflammation Research malnutrition inflammation score malnutrition crp/albumin ratio hemodialysis |
| title | Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients |
| title_full | Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients |
| title_fullStr | Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients |
| title_full_unstemmed | Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients |
| title_short | Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients |
| title_sort | independent association between malnutrition inflammation score and c reactive protein albumin ratio in hemodialysis patients |
| topic | malnutrition inflammation score malnutrition crp/albumin ratio hemodialysis |
| url | https://www.dovepress.com/independent-association-between-malnutrition-inflammation-score-and-c--peer-reviewed-fulltext-article-JIR |
| work_keys_str_mv | AT turk independentassociationbetweenmalnutritioninflammationscoreandcreactiveproteinalbuminratioinhemodialysispatients AT guclua independentassociationbetweenmalnutritioninflammationscoreandcreactiveproteinalbuminratioinhemodialysispatients |