A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma
Abstract The level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.4%) who undergo active surveillance...
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Nature Portfolio
2025-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57627-7 |
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| author | Genpeng Li Ruicen Li Jinjing Zhong Wenjie Chen Jinhao Shuai Meizhu Chen Feng Deng Tao Wei Huairong Tang Zhihui Li Jianyong Lei |
| author_facet | Genpeng Li Ruicen Li Jinjing Zhong Wenjie Chen Jinhao Shuai Meizhu Chen Feng Deng Tao Wei Huairong Tang Zhihui Li Jianyong Lei |
| author_sort | Genpeng Li |
| collection | DOAJ |
| description | Abstract The level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.4%) who undergo active surveillance (AS) express heightened regret based on validated decision regret scale (DRS) scores in the first online survey (P < 0.001). Multivariable analysis and the second online survey for patients with heightened regret confirm that postoperative lower thyroid cancer-specific quality of life (QoL) (scar and psychology) (75.5%) is the most common factor for heightened regret of thyroidectomy, followed by preoperative understanding of disease [not at all] (15.0%), presentation of complications (3.8%) and other factors (5.7%). These results highlight that more caution should be exercised when low-risk PTMC patients are scheduled for thyroidectomy. Information about the various treatments for clinically low-risk PTMC, the risk of thyroidectomy and postoperative QoL should be fully communicated during initial counseling. |
| format | Article |
| id | doaj-art-8e04eb900e5645c8bdaa09d2c297975e |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-8e04eb900e5645c8bdaa09d2c297975e2025-08-20T02:59:54ZengNature PortfolioNature Communications2041-17232025-03-0116111110.1038/s41467-025-57627-7A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinomaGenpeng Li0Ruicen Li1Jinjing Zhong2Wenjie Chen3Jinhao Shuai4Meizhu Chen5Feng Deng6Tao Wei7Huairong Tang8Zhihui Li9Jianyong Lei10Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan UniversityHealth and Management Center, General Practice Medical Center, West China Hospital, Sichuan UniversityDepartment of Pathology, West China Hospital of Sichuan UniversityDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan UniversityDepartment of Thyroid and Breast Surgery, Meishan City People’s HospitalDepartment of General Surgery, Sanya People’s HospitalDepartment of Stomach/Thyroid/Blood Vessel Surgery, Chongqing University Three Gorges HospitalDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan UniversityHealth and Management Center, General Practice Medical Center, West China Hospital, Sichuan UniversityDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan UniversityDivision of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan UniversityAbstract The level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.4%) who undergo active surveillance (AS) express heightened regret based on validated decision regret scale (DRS) scores in the first online survey (P < 0.001). Multivariable analysis and the second online survey for patients with heightened regret confirm that postoperative lower thyroid cancer-specific quality of life (QoL) (scar and psychology) (75.5%) is the most common factor for heightened regret of thyroidectomy, followed by preoperative understanding of disease [not at all] (15.0%), presentation of complications (3.8%) and other factors (5.7%). These results highlight that more caution should be exercised when low-risk PTMC patients are scheduled for thyroidectomy. Information about the various treatments for clinically low-risk PTMC, the risk of thyroidectomy and postoperative QoL should be fully communicated during initial counseling.https://doi.org/10.1038/s41467-025-57627-7 |
| spellingShingle | Genpeng Li Ruicen Li Jinjing Zhong Wenjie Chen Jinhao Shuai Meizhu Chen Feng Deng Tao Wei Huairong Tang Zhihui Li Jianyong Lei A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma Nature Communications |
| title | A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma |
| title_full | A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma |
| title_fullStr | A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma |
| title_full_unstemmed | A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma |
| title_short | A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma |
| title_sort | multicenter cohort study of thyroidectomy related decision regret in patients with low risk papillary thyroid microcarcinoma |
| url | https://doi.org/10.1038/s41467-025-57627-7 |
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