Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke
Post-stroke cognitive impairment (PSCI) is a common complication following a stroke that significantly affects patients’ quality of life and rehabilitation outcomes. It also imposes a heavy economic burden. There is an urgent need to better understand the pathophysiology and pathogenesis of PSCI, as...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1500650/full |
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| author | Huaqiang Li Huaqiang Li Xiaohua Ke Bianying Feng Huan Tian Huan Tian Zhenzhen Cai Anren Zhang Qiuhong Man |
| author_facet | Huaqiang Li Huaqiang Li Xiaohua Ke Bianying Feng Huan Tian Huan Tian Zhenzhen Cai Anren Zhang Qiuhong Man |
| author_sort | Huaqiang Li |
| collection | DOAJ |
| description | Post-stroke cognitive impairment (PSCI) is a common complication following a stroke that significantly affects patients’ quality of life and rehabilitation outcomes. It also imposes a heavy economic burden. There is an urgent need to better understand the pathophysiology and pathogenesis of PSCI, as well as to identify markers that can predict PSCI early in the clinical stage, facilitating early prevention, monitoring, and treatment. Although the mechanisms underlying PSCI are complex and multifaceted, involving factors such as atherosclerosis and neuroinflammation, metabolic disorders also play a critical role. This article primarily reviews the relationship between metabolic disorders of the three major nutrients—sugar, fat, and protein—and the development of cognitive dysfunction following ischemic stroke (IS). It aims to elucidate how these metabolic disturbances contribute to cognitive dysfunction post-stroke and to explore potential metabolic biomarkers for PSCI. We believe that this review will offer new insights into the early identification, treatment, and prognostic assessment of PSCI. |
| format | Article |
| id | doaj-art-8e01fd452f1542bf9803605b2c70cf5e |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-8e01fd452f1542bf9803605b2c70cf5e2025-01-22T05:19:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.15006501500650Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic strokeHuaqiang Li0Huaqiang Li1Xiaohua Ke2Bianying Feng3Huan Tian4Huan Tian5Zhenzhen Cai6Anren Zhang7Qiuhong Man8Department of Rehabilitation Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaPost-stroke cognitive impairment (PSCI) is a common complication following a stroke that significantly affects patients’ quality of life and rehabilitation outcomes. It also imposes a heavy economic burden. There is an urgent need to better understand the pathophysiology and pathogenesis of PSCI, as well as to identify markers that can predict PSCI early in the clinical stage, facilitating early prevention, monitoring, and treatment. Although the mechanisms underlying PSCI are complex and multifaceted, involving factors such as atherosclerosis and neuroinflammation, metabolic disorders also play a critical role. This article primarily reviews the relationship between metabolic disorders of the three major nutrients—sugar, fat, and protein—and the development of cognitive dysfunction following ischemic stroke (IS). It aims to elucidate how these metabolic disturbances contribute to cognitive dysfunction post-stroke and to explore potential metabolic biomarkers for PSCI. We believe that this review will offer new insights into the early identification, treatment, and prognostic assessment of PSCI.https://www.frontiersin.org/articles/10.3389/fendo.2025.1500650/fullischemic strokecognitive dysfunctionmetabolic disordersbiomarkersreview |
| spellingShingle | Huaqiang Li Huaqiang Li Xiaohua Ke Bianying Feng Huan Tian Huan Tian Zhenzhen Cai Anren Zhang Qiuhong Man Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke Frontiers in Endocrinology ischemic stroke cognitive dysfunction metabolic disorders biomarkers review |
| title | Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke |
| title_full | Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke |
| title_fullStr | Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke |
| title_full_unstemmed | Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke |
| title_short | Research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke |
| title_sort | research progress on the mechanism and markers of metabolic disorders in the occurrence and development of cognitive dysfunction after ischemic stroke |
| topic | ischemic stroke cognitive dysfunction metabolic disorders biomarkers review |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1500650/full |
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