Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review
Similar to human language, songbird singing is a complex motor skill learning behavior that is regulated by an interconnected network of neural nuclei in the brain. This network of nuclei demonstrates structural homology with human vocal control-related brain regions and shares common regulatory mec...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2025-06-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/19500.pdf |
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| author | Linghua Zhong Weiting Li Mengjiao Liu Wei Sun Zhibin Liu Songhua Wang |
| author_facet | Linghua Zhong Weiting Li Mengjiao Liu Wei Sun Zhibin Liu Songhua Wang |
| author_sort | Linghua Zhong |
| collection | DOAJ |
| description | Similar to human language, songbird singing is a complex motor skill learning behavior that is regulated by an interconnected network of neural nuclei in the brain. This network of nuclei demonstrates structural homology with human vocal control-related brain regions and shares common regulatory mechanisms for vocal learning. As an important neurotransmitter, dopamine plays a key role in the learning and maintenance of songbirds’ singing behavior. Studies have demonstrated that the dopaminergic system plays a critical role in regulating the plasticity of singing via the midbrain dopamine pathway, which projects to the song control circuit. Novel experimental techniques, such as optogenetic circuit manipulation and neural activity monitoring, have significantly advanced our understanding of the cellular and synaptic mechanisms underlying vocalization behavior of dopamine effects. This review offers an updated insight into the neural mechanisms by which dopamine modulates singing-related behavior, along with future prospects for utilizing dopamine in the treatment of speech-related disorders. |
| format | Article |
| id | doaj-art-8e01ebb780ca4663ad0804b0b40ebcc3 |
| institution | OA Journals |
| issn | 2167-8359 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-8e01ebb780ca4663ad0804b0b40ebcc32025-08-20T02:31:02ZengPeerJ Inc.PeerJ2167-83592025-06-0113e1950010.7717/peerj.19500Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated reviewLinghua Zhong0Weiting Li1Mengjiao Liu2Wei Sun3Zhibin Liu4Songhua Wang5School of Sports and Health, Jiangxi Science and Technology Normal University, Nanchang, ChinaSchool of Sports and Health, Jiangxi Science and Technology Normal University, Nanchang, ChinaJiangxi Provincial Key Laboratory of Organic Functional Molecules, Jiangxi Science and Technology Normal University, Nanchang, ChinaJiangxi Provincial Key Laboratory of Organic Functional Molecules, Jiangxi Science and Technology Normal University, Nanchang, ChinaSchool of Sports and Health, Jiangxi Science and Technology Normal University, Nanchang, ChinaJiangxi Provincial Key Laboratory of Organic Functional Molecules, Jiangxi Science and Technology Normal University, Nanchang, ChinaSimilar to human language, songbird singing is a complex motor skill learning behavior that is regulated by an interconnected network of neural nuclei in the brain. This network of nuclei demonstrates structural homology with human vocal control-related brain regions and shares common regulatory mechanisms for vocal learning. As an important neurotransmitter, dopamine plays a key role in the learning and maintenance of songbirds’ singing behavior. Studies have demonstrated that the dopaminergic system plays a critical role in regulating the plasticity of singing via the midbrain dopamine pathway, which projects to the song control circuit. Novel experimental techniques, such as optogenetic circuit manipulation and neural activity monitoring, have significantly advanced our understanding of the cellular and synaptic mechanisms underlying vocalization behavior of dopamine effects. This review offers an updated insight into the neural mechanisms by which dopamine modulates singing-related behavior, along with future prospects for utilizing dopamine in the treatment of speech-related disorders.https://peerj.com/articles/19500.pdfDopamineSongbirdSinging behaviorSong control system |
| spellingShingle | Linghua Zhong Weiting Li Mengjiao Liu Wei Sun Zhibin Liu Songhua Wang Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review PeerJ Dopamine Songbird Singing behavior Song control system |
| title | Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review |
| title_full | Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review |
| title_fullStr | Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review |
| title_full_unstemmed | Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review |
| title_short | Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review |
| title_sort | neural mechanism of dopamine modulating singing related behavior in songbirds an updated review |
| topic | Dopamine Songbird Singing behavior Song control system |
| url | https://peerj.com/articles/19500.pdf |
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