Controllable ultrahigh-affinity molecular recognition
High-affinity molecular recognition plays a crucial role in both biological and artificial host-guest systems, ensuring robustness in complex environments or at extremely low concentrations. Achieving exceptionally high binding affinity in artificial receptors remains a fundamental challenge for sup...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Supramolecular Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667240525000108 |
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| author | Fang-Yuan Chen Han-Fang Zhang Kang Cai Dong-Sheng Guo |
| author_facet | Fang-Yuan Chen Han-Fang Zhang Kang Cai Dong-Sheng Guo |
| author_sort | Fang-Yuan Chen |
| collection | DOAJ |
| description | High-affinity molecular recognition plays a crucial role in both biological and artificial host-guest systems, ensuring robustness in complex environments or at extremely low concentrations. Achieving exceptionally high binding affinity in artificial receptors remains a fundamental challenge for supramolecular chemistry. However, while ultrahigh binding affinity is desirable for stability, it may limit the dynamic behavior of host-guest systems, thereby restricting potential applications. Hence, controllable ultrahigh-affinity molecular recognition (CUAMR) systems allow guest release in response to precise stimuli (such as photo, pH and redox), which hold significant promise across diverse fields. This paper focuses on the introduction of CUAMR and functional applications of such controllable systems, highlighting current challenges and future prospects. |
| format | Article |
| id | doaj-art-8dfe5c5003644b4494f503f0ddddf70e |
| institution | Kabale University |
| issn | 2667-2405 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Supramolecular Materials |
| spelling | doaj-art-8dfe5c5003644b4494f503f0ddddf70e2025-08-20T03:41:10ZengKeAi Communications Co., Ltd.Supramolecular Materials2667-24052025-12-01410010110.1016/j.supmat.2025.100101Controllable ultrahigh-affinity molecular recognitionFang-Yuan Chen0Han-Fang Zhang1Kang Cai2Dong-Sheng Guo3College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR ChinaCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR ChinaCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, PR China; Corresponding authors.College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, PR China; Corresponding authors.High-affinity molecular recognition plays a crucial role in both biological and artificial host-guest systems, ensuring robustness in complex environments or at extremely low concentrations. Achieving exceptionally high binding affinity in artificial receptors remains a fundamental challenge for supramolecular chemistry. However, while ultrahigh binding affinity is desirable for stability, it may limit the dynamic behavior of host-guest systems, thereby restricting potential applications. Hence, controllable ultrahigh-affinity molecular recognition (CUAMR) systems allow guest release in response to precise stimuli (such as photo, pH and redox), which hold significant promise across diverse fields. This paper focuses on the introduction of CUAMR and functional applications of such controllable systems, highlighting current challenges and future prospects.http://www.sciencedirect.com/science/article/pii/S2667240525000108Molecular recognitionUltrahigh-affinityControlled releaseMacrocyclesBioapplications |
| spellingShingle | Fang-Yuan Chen Han-Fang Zhang Kang Cai Dong-Sheng Guo Controllable ultrahigh-affinity molecular recognition Supramolecular Materials Molecular recognition Ultrahigh-affinity Controlled release Macrocycles Bioapplications |
| title | Controllable ultrahigh-affinity molecular recognition |
| title_full | Controllable ultrahigh-affinity molecular recognition |
| title_fullStr | Controllable ultrahigh-affinity molecular recognition |
| title_full_unstemmed | Controllable ultrahigh-affinity molecular recognition |
| title_short | Controllable ultrahigh-affinity molecular recognition |
| title_sort | controllable ultrahigh affinity molecular recognition |
| topic | Molecular recognition Ultrahigh-affinity Controlled release Macrocycles Bioapplications |
| url | http://www.sciencedirect.com/science/article/pii/S2667240525000108 |
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