The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response
Abstract Background We aimed to perform a review focused on the effects of dexamethasone on markers of surgical stress in the context of laparoscopic abdominal surgery. Methods This review was registered at PROSPERO. Published reports were evaluated with COVIDENCE, focusing on randomized controlled...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
|
| Series: | BMC Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12893-025-03061-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849767080426995712 |
|---|---|
| author | Karsten Kaiser Sven Hoedt Karstensen Alexandros Nikolaou Valsamides Valorenzos Kristian Als Nielsen Thomas Strøm Ismail Gögenur Lukas Balsevicius Finn Friis Lauszus |
| author_facet | Karsten Kaiser Sven Hoedt Karstensen Alexandros Nikolaou Valsamides Valorenzos Kristian Als Nielsen Thomas Strøm Ismail Gögenur Lukas Balsevicius Finn Friis Lauszus |
| author_sort | Karsten Kaiser |
| collection | DOAJ |
| description | Abstract Background We aimed to perform a review focused on the effects of dexamethasone on markers of surgical stress in the context of laparoscopic abdominal surgery. Methods This review was registered at PROSPERO. Published reports were evaluated with COVIDENCE, focusing on randomized controlled trials from the MEDLINE, EMBASE and CENTRAL databases. Studies were included if they compared a single intravenous dose of dexamethasone to placebo given preoperatively to adult patients undergoing laparoscopic or robotic assisted abdominal surgery under general anesthesia. The outcome of interest was inflammatory response in general and in particular c-reactive protein. Results Out of 588 references, we included seven studies. These involved a variety of surgical procedures, with cholecystectomies being the most common, and included mixed gender populations except in studies on gynecology surgery. Due to the heterogeneity in outcomes and the low number of studies no meta-analysis was performed. Levels of c-reactive protein was 38-60 % lower at 24 to 48 hours postoperatively with a dose of 8 mg dexamethasone compared to placebo, predominantly in cholecystectomy cases. Post-trial calculation indicates that the power of these studies ranged between 60% and 95%. Conclusion Our review may indicate a reduction of surgical stress in laparoscopic abdominal surgery measured by c-reactive protein, when a single dose of dexamethasone is administered. Trial registration PROSPERO: CRD 42024421062. |
| format | Article |
| id | doaj-art-8dfdab8748ba436ebfdafc0cfd1fabaf |
| institution | DOAJ |
| issn | 1471-2482 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Surgery |
| spelling | doaj-art-8dfdab8748ba436ebfdafc0cfd1fabaf2025-08-20T03:04:21ZengBMCBMC Surgery1471-24822025-08-012511910.1186/s12893-025-03061-xThe effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress responseKarsten Kaiser0Sven Hoedt Karstensen1Alexandros Nikolaou Valsamides Valorenzos2Kristian Als Nielsen3Thomas Strøm4Ismail Gögenur5Lukas Balsevicius6Finn Friis Lauszus7Department of Gynecology and Obstetrics, Aabenraa Hospital, Sygehus SønderjyllandDepartment of Gynecology and Obstetrics, Aabenraa Hospital, Sygehus SønderjyllandDepartment of Gynecology and Surgery Aabenraa Hospital, Sygehus SønderjyllandDepartment of Gynecology and Surgery Aabenraa Hospital, Sygehus SønderjyllandDepartment of Anesthesia and Critical Care Medicine, Hospital Sønderjylland, University of Southern DenmarkDepartment of Surgery, Zealand University HospitalDepartment of Surgery, Zealand University HospitalDepartment of Gynecology and Obstetrics, Aabenraa Hospital, Sygehus SønderjyllandAbstract Background We aimed to perform a review focused on the effects of dexamethasone on markers of surgical stress in the context of laparoscopic abdominal surgery. Methods This review was registered at PROSPERO. Published reports were evaluated with COVIDENCE, focusing on randomized controlled trials from the MEDLINE, EMBASE and CENTRAL databases. Studies were included if they compared a single intravenous dose of dexamethasone to placebo given preoperatively to adult patients undergoing laparoscopic or robotic assisted abdominal surgery under general anesthesia. The outcome of interest was inflammatory response in general and in particular c-reactive protein. Results Out of 588 references, we included seven studies. These involved a variety of surgical procedures, with cholecystectomies being the most common, and included mixed gender populations except in studies on gynecology surgery. Due to the heterogeneity in outcomes and the low number of studies no meta-analysis was performed. Levels of c-reactive protein was 38-60 % lower at 24 to 48 hours postoperatively with a dose of 8 mg dexamethasone compared to placebo, predominantly in cholecystectomy cases. Post-trial calculation indicates that the power of these studies ranged between 60% and 95%. Conclusion Our review may indicate a reduction of surgical stress in laparoscopic abdominal surgery measured by c-reactive protein, when a single dose of dexamethasone is administered. Trial registration PROSPERO: CRD 42024421062.https://doi.org/10.1186/s12893-025-03061-xC-reactive proteinDexamethasoneLaparoscopyRandomized controlled trialInflammationReview |
| spellingShingle | Karsten Kaiser Sven Hoedt Karstensen Alexandros Nikolaou Valsamides Valorenzos Kristian Als Nielsen Thomas Strøm Ismail Gögenur Lukas Balsevicius Finn Friis Lauszus The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response BMC Surgery C-reactive protein Dexamethasone Laparoscopy Randomized controlled trial Inflammation Review |
| title | The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response |
| title_full | The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response |
| title_fullStr | The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response |
| title_full_unstemmed | The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response |
| title_short | The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response |
| title_sort | effect of dexamethasone in laparoscopic abdominal surgery a review on inflammatory markers for stress response |
| topic | C-reactive protein Dexamethasone Laparoscopy Randomized controlled trial Inflammation Review |
| url | https://doi.org/10.1186/s12893-025-03061-x |
| work_keys_str_mv | AT karstenkaiser theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT svenhoedtkarstensen theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT alexandrosnikolaouvalsamidesvalorenzos theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT kristianalsnielsen theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT thomasstrøm theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT ismailgogenur theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT lukasbalsevicius theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT finnfriislauszus theeffectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT karstenkaiser effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT svenhoedtkarstensen effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT alexandrosnikolaouvalsamidesvalorenzos effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT kristianalsnielsen effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT thomasstrøm effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT ismailgogenur effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT lukasbalsevicius effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse AT finnfriislauszus effectofdexamethasoneinlaparoscopicabdominalsurgeryareviewoninflammatorymarkersforstressresponse |