Tick exposure biomarkers: A One Health approach to new tick surveillance tools
The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies. Ticks can transmit a range of pathogens increasing the risk of transmission of human and veterinary...
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Elsevier
2024-01-01
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| Series: | Current Research in Parasitology and Vector-Borne Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667114X24000438 |
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| author | Alexis Dziedziech Eva Krupa Kristina E.M. Persson Richard Paul Sarah Bonnet |
| author_facet | Alexis Dziedziech Eva Krupa Kristina E.M. Persson Richard Paul Sarah Bonnet |
| author_sort | Alexis Dziedziech |
| collection | DOAJ |
| description | The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies. Ticks can transmit a range of pathogens increasing the risk of transmission of human and veterinary diseases such as Lyme disease, tick-borne encephalitis, theileriosis, anaplasmosis, or Crimean-Congo hemorrhagic fever. Surveillance methods play a crucial role in monitoring the spread of tick-borne pathogens (TBP). However, there are shortcomings in the current surveillance methods regarding risks related to ticks. Human-tick encounters offer a novel metric for disease risk assessment, integrating human behavior into traditional surveillance models. However, to more reliably measure tick exposure, a molecular marker is needed. The identification of antibodies against arthropod salivary proteins as biomarkers for vector exposure represents a promising avenue for enhancing existing diagnostic and surveillance metrics. Here we explore how the use of tick saliva biomarkers targeting recombinant proteins and synthetic peptides could significantly improve the assessment of TBD transmission risk and the effectiveness of vector control measures. With focused efforts on creating a biomarker against tick exposure suitable for humans and domestic animals alike, tick surveillance, diagnosis and control would be more achievable and aid in reducing the mounting threat of TBP through a One Health lens. |
| format | Article |
| id | doaj-art-8dfa1af4ee1b42dd8ee11311ef9fec16 |
| institution | OA Journals |
| issn | 2667-114X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Parasitology and Vector-Borne Diseases |
| spelling | doaj-art-8dfa1af4ee1b42dd8ee11311ef9fec162025-08-20T02:07:31ZengElsevierCurrent Research in Parasitology and Vector-Borne Diseases2667-114X2024-01-01610021210.1016/j.crpvbd.2024.100212Tick exposure biomarkers: A One Health approach to new tick surveillance toolsAlexis Dziedziech0Eva Krupa1Kristina E.M. Persson2Richard Paul3Sarah Bonnet4Institut Pasteur, Université Paris Cité, CNRS UMR 2000, INRAE USC 1510, Ecology and Emergence of Arthropod-borne Pathogens Unit, F-75015, Paris, France; Department of Laboratory Medicine, Lund University, Lund, Sweden; Corresponding author.Institut Pasteur, Université Paris Cité, CNRS UMR 2000, INRAE USC 1510, Ecology and Emergence of Arthropod-borne pathogens unit, F-75015 Paris, FranceInstitut Pasteur, Université Paris Cité, CNRS UMR 2000, INRAE USC 1510, Ecology and Emergence of Arthropod-borne Pathogens Unit, F-75015, Paris, FranceDepartment of Laboratory Medicine, Lund University, Lund, Sweden; Clinical Chemistry and Pharmacology, Laboratory Medicine, Office for Medical Services, Region Skåne, Lund, SwedenInstitut Pasteur, Université Paris Cité, CNRS UMR 2000, INRAE USC 1510, Ecology and Emergence of Arthropod-borne Pathogens Unit, F-75015, Paris, FranceInstitut Pasteur, Université Paris Cité, CNRS UMR 2000, INRAE USC 1510, Ecology and Emergence of Arthropod-borne Pathogens Unit, F-75015, Paris, France; Corresponding author.The spread of tick-borne disease (TBD) is escalating globally, driven by climate change and socio-economic shifts, underlining the urgency to improve surveillance, diagnostics, and control strategies. Ticks can transmit a range of pathogens increasing the risk of transmission of human and veterinary diseases such as Lyme disease, tick-borne encephalitis, theileriosis, anaplasmosis, or Crimean-Congo hemorrhagic fever. Surveillance methods play a crucial role in monitoring the spread of tick-borne pathogens (TBP). However, there are shortcomings in the current surveillance methods regarding risks related to ticks. Human-tick encounters offer a novel metric for disease risk assessment, integrating human behavior into traditional surveillance models. However, to more reliably measure tick exposure, a molecular marker is needed. The identification of antibodies against arthropod salivary proteins as biomarkers for vector exposure represents a promising avenue for enhancing existing diagnostic and surveillance metrics. Here we explore how the use of tick saliva biomarkers targeting recombinant proteins and synthetic peptides could significantly improve the assessment of TBD transmission risk and the effectiveness of vector control measures. With focused efforts on creating a biomarker against tick exposure suitable for humans and domestic animals alike, tick surveillance, diagnosis and control would be more achievable and aid in reducing the mounting threat of TBP through a One Health lens.http://www.sciencedirect.com/science/article/pii/S2667114X24000438Tick exposureBiomarkersTick salivaImmunogenic peptidesBiomarker discoveryAntigenic peptides |
| spellingShingle | Alexis Dziedziech Eva Krupa Kristina E.M. Persson Richard Paul Sarah Bonnet Tick exposure biomarkers: A One Health approach to new tick surveillance tools Current Research in Parasitology and Vector-Borne Diseases Tick exposure Biomarkers Tick saliva Immunogenic peptides Biomarker discovery Antigenic peptides |
| title | Tick exposure biomarkers: A One Health approach to new tick surveillance tools |
| title_full | Tick exposure biomarkers: A One Health approach to new tick surveillance tools |
| title_fullStr | Tick exposure biomarkers: A One Health approach to new tick surveillance tools |
| title_full_unstemmed | Tick exposure biomarkers: A One Health approach to new tick surveillance tools |
| title_short | Tick exposure biomarkers: A One Health approach to new tick surveillance tools |
| title_sort | tick exposure biomarkers a one health approach to new tick surveillance tools |
| topic | Tick exposure Biomarkers Tick saliva Immunogenic peptides Biomarker discovery Antigenic peptides |
| url | http://www.sciencedirect.com/science/article/pii/S2667114X24000438 |
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