Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysis

Abstract Objectives We aimed to conduct a systematic review and meta‐analysis to assess the value of image‐enhanced endoscopy including blue laser imaging (BLI), linked color imaging, narrow‐band imaging (NBI), and texture and color enhancement imaging to detect and diagnose gastric cancer (GC) comp...

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Main Authors: Osamu Dohi, Mayuko Seya, Naoto Iwai, Tomoko Ochiai, Junki Yumoto, Hiroki Mukai, Katsuma Yamauchi, Reo Kobayashi, Ryohei Hirose, Ken Inoue, Naohisa Yoshida, Hideyuki Konishi, Yoshito Itoh
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:DEN Open
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Online Access:https://doi.org/10.1002/deo2.418
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author Osamu Dohi
Mayuko Seya
Naoto Iwai
Tomoko Ochiai
Junki Yumoto
Hiroki Mukai
Katsuma Yamauchi
Reo Kobayashi
Ryohei Hirose
Ken Inoue
Naohisa Yoshida
Hideyuki Konishi
Yoshito Itoh
author_facet Osamu Dohi
Mayuko Seya
Naoto Iwai
Tomoko Ochiai
Junki Yumoto
Hiroki Mukai
Katsuma Yamauchi
Reo Kobayashi
Ryohei Hirose
Ken Inoue
Naohisa Yoshida
Hideyuki Konishi
Yoshito Itoh
author_sort Osamu Dohi
collection DOAJ
description Abstract Objectives We aimed to conduct a systematic review and meta‐analysis to assess the value of image‐enhanced endoscopy including blue laser imaging (BLI), linked color imaging, narrow‐band imaging (NBI), and texture and color enhancement imaging to detect and diagnose gastric cancer (GC) compared to that of white‐light imaging (WLI). Methods Studies meeting the inclusion criteria were identified through PubMed, Cochrane Library, and Japan Medical Abstracts Society databases searches. The pooled risk ratio for dichotomous variables was calculated using the random‐effects model to assess the GC detection between WLI and image‐enhanced endoscopy. A random‐effects model was used to calculate the overall diagnostic performance of WLI and magnifying image‐enhanced endoscopy for GC. Results Sixteen studies met the inclusion criteria. The detection rate of GC was significantly improved in linked color imaging compared with that in WLI (risk ratio, 2.20; 95% confidence interval [CI], 1.39–3.25; p < 0.01) with mild heterogeneity. Magnifying endoscopy with NBI (ME‐NBI) obtained a pooled sensitivity, specificity, and area under the summary receiver operating curve of 0.84 (95 % CI, 0.80–0.88), 0.96 (95 % CI, 0.94–0.97), and 0.92, respectively. Similarly, ME‐BLI showed a pooled sensitivity, specificity, and area under the curve of 0.81 (95 % CI, 0.77–0.85), 0.85 (95 % CI, 0.82–0.88), and 0.95, respectively. The diagnostic efficacy of ME‐NBI/BLI for GC was evidently high compared to that of WLI, However, significant heterogeneity among the NBI studies still existed. Conclusions Our meta‐analysis showed a high detection rate for linked color imaging and a high diagnostic performance of ME‐NBI/BLI for GC compared to that with WLI.
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spelling doaj-art-8df99f43d7e240bb87a98e3e5cb8c8262025-08-20T03:13:50ZengWileyDEN Open2692-46092025-04-0151n/an/a10.1002/deo2.418Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysisOsamu Dohi0Mayuko Seya1Naoto Iwai2Tomoko Ochiai3Junki Yumoto4Hiroki Mukai5Katsuma Yamauchi6Reo Kobayashi7Ryohei Hirose8Ken Inoue9Naohisa Yoshida10Hideyuki Konishi11Yoshito Itoh12Molecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanMolecular Gastroenterology and Hepatology Graduate School of Medicine, Kyoto Prefectural University of Medicine Kyoto JapanAbstract Objectives We aimed to conduct a systematic review and meta‐analysis to assess the value of image‐enhanced endoscopy including blue laser imaging (BLI), linked color imaging, narrow‐band imaging (NBI), and texture and color enhancement imaging to detect and diagnose gastric cancer (GC) compared to that of white‐light imaging (WLI). Methods Studies meeting the inclusion criteria were identified through PubMed, Cochrane Library, and Japan Medical Abstracts Society databases searches. The pooled risk ratio for dichotomous variables was calculated using the random‐effects model to assess the GC detection between WLI and image‐enhanced endoscopy. A random‐effects model was used to calculate the overall diagnostic performance of WLI and magnifying image‐enhanced endoscopy for GC. Results Sixteen studies met the inclusion criteria. The detection rate of GC was significantly improved in linked color imaging compared with that in WLI (risk ratio, 2.20; 95% confidence interval [CI], 1.39–3.25; p < 0.01) with mild heterogeneity. Magnifying endoscopy with NBI (ME‐NBI) obtained a pooled sensitivity, specificity, and area under the summary receiver operating curve of 0.84 (95 % CI, 0.80–0.88), 0.96 (95 % CI, 0.94–0.97), and 0.92, respectively. Similarly, ME‐BLI showed a pooled sensitivity, specificity, and area under the curve of 0.81 (95 % CI, 0.77–0.85), 0.85 (95 % CI, 0.82–0.88), and 0.95, respectively. The diagnostic efficacy of ME‐NBI/BLI for GC was evidently high compared to that of WLI, However, significant heterogeneity among the NBI studies still existed. Conclusions Our meta‐analysis showed a high detection rate for linked color imaging and a high diagnostic performance of ME‐NBI/BLI for GC compared to that with WLI.https://doi.org/10.1002/deo2.418blue laser imaginggastric cancerimage‐enhanced endoscopylinked color imagingnarrow‐band imaging
spellingShingle Osamu Dohi
Mayuko Seya
Naoto Iwai
Tomoko Ochiai
Junki Yumoto
Hiroki Mukai
Katsuma Yamauchi
Reo Kobayashi
Ryohei Hirose
Ken Inoue
Naohisa Yoshida
Hideyuki Konishi
Yoshito Itoh
Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysis
DEN Open
blue laser imaging
gastric cancer
image‐enhanced endoscopy
linked color imaging
narrow‐band imaging
title Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysis
title_full Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysis
title_fullStr Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysis
title_full_unstemmed Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysis
title_short Endoscopic detection and diagnosis of gastric cancer using image‐enhanced endoscopy: A systematic review and meta‐analysis
title_sort endoscopic detection and diagnosis of gastric cancer using image enhanced endoscopy a systematic review and meta analysis
topic blue laser imaging
gastric cancer
image‐enhanced endoscopy
linked color imaging
narrow‐band imaging
url https://doi.org/10.1002/deo2.418
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