Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated setting

IntroductionPreterm infants’ growth is typically monitored through weight, body length (BL) and head circumference (HC). However, 3D cranial volume (CrV) is considered a more accurate indicator of brain growth than 2D HC. The PreemieScanner is a novel 3D measuring device that simultaneously measures...

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Main Authors: Ronald H. J. van Gils, Onno K. Helder, René F. Kornelisse, Timothy M. S. Singowikromo, Irwin Reiss, Jenny Dankelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Medical Technology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmedt.2025.1607538/full
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author Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Onno K. Helder
Onno K. Helder
René F. Kornelisse
Timothy M. S. Singowikromo
Irwin Reiss
Jenny Dankelman
author_facet Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Onno K. Helder
Onno K. Helder
René F. Kornelisse
Timothy M. S. Singowikromo
Irwin Reiss
Jenny Dankelman
author_sort Ronald H. J. van Gils
collection DOAJ
description IntroductionPreterm infants’ growth is typically monitored through weight, body length (BL) and head circumference (HC). However, 3D cranial volume (CrV) is considered a more accurate indicator of brain growth than 2D HC. The PreemieScanner is a novel 3D measuring device that simultaneously measures BL, HC and CrV. Its clinical usability was tested in a simulated NICU setting.Materials and methodsThree extremely low birth weight (ELBW; BW < 1,000 gram) dolls with Optiflow breathing systems, (tubes positioned either at the front or back of the head) were used. Nurses conducted scan sessions and marked anatomical landmarks on 3D PreemieScanner images. As control, nurses measured HC manually with a standard measuring tape. Key outcomes were: (1) Measurement success rate, (2) Precision—percentage within clinically allowed limits, ±0.4 cm for BL, ±0.3 cm for HC, ±12 ml for CrV, and 3) accuracy—mean or median measurement error (MME) relative to the ground truth.ResultsThirty-five scan sessions resulted in 100% successful measurements for BL and HC; 80% for CrV. BL MME −3.3% (p < 0.001); 40% (42/105) within precision limits. HC MME (Optiflow-front) 0.0% (p = 0.63); 89% (51/57) within limits. HC MME (Optiflow-back) −0.4% (p = 0.91). 93% (43/46) within limits. MME HC measuring tape, (Optiflow-front) −0.8% (p < 0.001), 88% (50/57) within limits, and MME (Optiflow-back) −1.1% (p < 0.001), 83% (40/48) within limits. MME CrV (Optiflow-front) −1.8% (p = 0.01), 86% (31/36) within limits, MME CrV (Optiflow-back) −1.3% (p < 0.001), 98% (45/46) within limits.ConclusionsThe PreemieScanner is a reliable, comprehensive device for measuring BL, HC and CrV in ELBW infants. It integrates smoothly into routine care with minimal disturbance. HC measurements demonstrated higher accuracy and precision than traditional tape method. CrV measurements, with 93% within precision limits, can be regarded as acceptable, enabling development of CrV growth reference charts, enhancing clinical growth monitoring.
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spelling doaj-art-8df8016cfd934056a31f6c7f55df24252025-08-20T03:58:18ZengFrontiers Media S.A.Frontiers in Medical Technology2673-31292025-08-01710.3389/fmedt.2025.16075381607538Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated settingRonald H. J. van Gils0Ronald H. J. van Gils1Ronald H. J. van Gils2Ronald H. J. van Gils3Ronald H. J. van Gils4Onno K. Helder5Onno K. Helder6René F. Kornelisse7Timothy M. S. Singowikromo8Irwin Reiss9Jenny Dankelman10Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC University Medical Center, Rotterdam, NetherlandsDepartment of Create4Care, Erasmus MC University Medical Center, Rotterdam, NetherlandsDepartment of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology, Delft, NetherlandsResearch Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, NetherlandsInstitute of Engineering & Applied Science, Rotterdam University of Applied Sciences, Rotterdam, NetherlandsDepartment of Create4Care, Erasmus MC University Medical Center, Rotterdam, NetherlandsResearch Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, NetherlandsDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC University Medical Center, Rotterdam, NetherlandsDepartment of Create4Care, Erasmus MC University Medical Center, Rotterdam, NetherlandsDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC University Medical Center, Rotterdam, NetherlandsDepartment of Biomechanical Engineering, Faculty of Mechanical Engineering, Delft University of Technology, Delft, NetherlandsIntroductionPreterm infants’ growth is typically monitored through weight, body length (BL) and head circumference (HC). However, 3D cranial volume (CrV) is considered a more accurate indicator of brain growth than 2D HC. The PreemieScanner is a novel 3D measuring device that simultaneously measures BL, HC and CrV. Its clinical usability was tested in a simulated NICU setting.Materials and methodsThree extremely low birth weight (ELBW; BW < 1,000 gram) dolls with Optiflow breathing systems, (tubes positioned either at the front or back of the head) were used. Nurses conducted scan sessions and marked anatomical landmarks on 3D PreemieScanner images. As control, nurses measured HC manually with a standard measuring tape. Key outcomes were: (1) Measurement success rate, (2) Precision—percentage within clinically allowed limits, ±0.4 cm for BL, ±0.3 cm for HC, ±12 ml for CrV, and 3) accuracy—mean or median measurement error (MME) relative to the ground truth.ResultsThirty-five scan sessions resulted in 100% successful measurements for BL and HC; 80% for CrV. BL MME −3.3% (p < 0.001); 40% (42/105) within precision limits. HC MME (Optiflow-front) 0.0% (p = 0.63); 89% (51/57) within limits. HC MME (Optiflow-back) −0.4% (p = 0.91). 93% (43/46) within limits. MME HC measuring tape, (Optiflow-front) −0.8% (p < 0.001), 88% (50/57) within limits, and MME (Optiflow-back) −1.1% (p < 0.001), 83% (40/48) within limits. MME CrV (Optiflow-front) −1.8% (p = 0.01), 86% (31/36) within limits, MME CrV (Optiflow-back) −1.3% (p < 0.001), 98% (45/46) within limits.ConclusionsThe PreemieScanner is a reliable, comprehensive device for measuring BL, HC and CrV in ELBW infants. It integrates smoothly into routine care with minimal disturbance. HC measurements demonstrated higher accuracy and precision than traditional tape method. CrV measurements, with 93% within precision limits, can be regarded as acceptable, enabling development of CrV growth reference charts, enhancing clinical growth monitoring.https://www.frontiersin.org/articles/10.3389/fmedt.2025.1607538/fullgrowth monitoringneonatal intensive care unit (NICU)preterm infantsextremely low birth weight infants (ELBW infants)3D scanning and measuringhead circumference (HC)
spellingShingle Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Ronald H. J. van Gils
Onno K. Helder
Onno K. Helder
René F. Kornelisse
Timothy M. S. Singowikromo
Irwin Reiss
Jenny Dankelman
Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated setting
Frontiers in Medical Technology
growth monitoring
neonatal intensive care unit (NICU)
preterm infants
extremely low birth weight infants (ELBW infants)
3D scanning and measuring
head circumference (HC)
title Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated setting
title_full Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated setting
title_fullStr Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated setting
title_full_unstemmed Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated setting
title_short Effectiveness of the novel 3D PreemieScanner for preterm infants’ growth monitoring confirmed in a simulated setting
title_sort effectiveness of the novel 3d preemiescanner for preterm infants growth monitoring confirmed in a simulated setting
topic growth monitoring
neonatal intensive care unit (NICU)
preterm infants
extremely low birth weight infants (ELBW infants)
3D scanning and measuring
head circumference (HC)
url https://www.frontiersin.org/articles/10.3389/fmedt.2025.1607538/full
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