Unveiling promising sepsis biomarkers: a clinical perspective
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It is characterized by a high incidence, high mortality rate, and poor prognosis. With the increasing consumption of antibiotics and the growing prevalence of antimicrobial resistance, clinic...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | All Life |
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| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2369569 |
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| author | Hong Zhang Junpeng Zhao Zhiping Wang Mengxiang Huang Zhonghua Tan Feng Jiang Yuhong Zhou Linhua Wang Mingbing Xiao |
| author_facet | Hong Zhang Junpeng Zhao Zhiping Wang Mengxiang Huang Zhonghua Tan Feng Jiang Yuhong Zhou Linhua Wang Mingbing Xiao |
| author_sort | Hong Zhang |
| collection | DOAJ |
| description | Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It is characterized by a high incidence, high mortality rate, and poor prognosis. With the increasing consumption of antibiotics and the growing prevalence of antimicrobial resistance, clinicians are in greater need of easily accessible and effective inflammatory markers to monitor the infection process, guide treatment, and assess patient prognosis. Numerous biomarkers have been studied for their potential value in the diagnosis of sepsis, and more than 250 different biomarkers have been proposed. However, many of these biomarkers are more useful for prognostic evaluation than for diagnosis. Biomarkers such as procalcitonin and C-reactive protein have been extensively studied, with procalcitonin being the only sepsis biomarker included in clinical guidelines. It can be used to guide antibiotic use but should not be used as a standalone diagnostic indicator. C-reactive protein has poor sensitivity and specificity for sepsis diagnosis. In recent years, new biomarkers, such as neutrophil extracellular traps, interleukin-6, histones, cell-free DNA and composite indicators, such as the systemic immune inflammation index,have been identified. This article provides a comprehensive review of the diagnostic value of traditional and recently popular novel biomarkers for sepsis. |
| format | Article |
| id | doaj-art-8df2a49edc2b45bbb44ee0c3f29c90c0 |
| institution | Kabale University |
| issn | 2689-5307 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj-art-8df2a49edc2b45bbb44ee0c3f29c90c02025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.23695692369569Unveiling promising sepsis biomarkers: a clinical perspectiveHong Zhang0Junpeng Zhao1Zhiping Wang2Mengxiang Huang3Zhonghua Tan4Feng Jiang5Yuhong Zhou6Linhua Wang7Mingbing Xiao8Affiliated Hospital and medical School of Nantong UniversityAffiliated Hospital and medical School of Nantong UniversityAffiliated Hospital and medical School of Nantong UniversityAffiliated Hospital and medical School of Nantong UniversityAffiliated Hospital of Nantong UniversityAffiliated Hospital and medical School of Nantong UniversityJiangsu Province Hospital of Chinese MedicineAffiliated Hospital and medical School of Nantong UniversityAffiliated Hospital and medical School of Nantong UniversitySepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. It is characterized by a high incidence, high mortality rate, and poor prognosis. With the increasing consumption of antibiotics and the growing prevalence of antimicrobial resistance, clinicians are in greater need of easily accessible and effective inflammatory markers to monitor the infection process, guide treatment, and assess patient prognosis. Numerous biomarkers have been studied for their potential value in the diagnosis of sepsis, and more than 250 different biomarkers have been proposed. However, many of these biomarkers are more useful for prognostic evaluation than for diagnosis. Biomarkers such as procalcitonin and C-reactive protein have been extensively studied, with procalcitonin being the only sepsis biomarker included in clinical guidelines. It can be used to guide antibiotic use but should not be used as a standalone diagnostic indicator. C-reactive protein has poor sensitivity and specificity for sepsis diagnosis. In recent years, new biomarkers, such as neutrophil extracellular traps, interleukin-6, histones, cell-free DNA and composite indicators, such as the systemic immune inflammation index,have been identified. This article provides a comprehensive review of the diagnostic value of traditional and recently popular novel biomarkers for sepsis.http://dx.doi.org/10.1080/26895293.2024.2369569sepsisbiomarkersprocalcitoninneutrophil extracellular trapscfdna systemic immune inflammation index |
| spellingShingle | Hong Zhang Junpeng Zhao Zhiping Wang Mengxiang Huang Zhonghua Tan Feng Jiang Yuhong Zhou Linhua Wang Mingbing Xiao Unveiling promising sepsis biomarkers: a clinical perspective All Life sepsis biomarkers procalcitonin neutrophil extracellular traps cfdna systemic immune inflammation index |
| title | Unveiling promising sepsis biomarkers: a clinical perspective |
| title_full | Unveiling promising sepsis biomarkers: a clinical perspective |
| title_fullStr | Unveiling promising sepsis biomarkers: a clinical perspective |
| title_full_unstemmed | Unveiling promising sepsis biomarkers: a clinical perspective |
| title_short | Unveiling promising sepsis biomarkers: a clinical perspective |
| title_sort | unveiling promising sepsis biomarkers a clinical perspective |
| topic | sepsis biomarkers procalcitonin neutrophil extracellular traps cfdna systemic immune inflammation index |
| url | http://dx.doi.org/10.1080/26895293.2024.2369569 |
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